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Submit ReviewBAY-X 1005
说明： Orally active 5-lipoxygenase activating protein (FLAP) inhibitor
化学名： (R)-α-Cyclopentyl-4-(2-quinolinylmethoxy)benzeneacetic acid
纯度： ≥98% (HPLC)
生物活性 for BAY-X 1005
BAY-X 1005 is a 5-lipoxygenase activating protein (FLAP) inhibitor. Inhibits the synthesis of leukotrienes B4 and C4 in animal models; inhibits synthesis of leukotriene B4 in A23187-stimulated leukocytes (IC50 values are 0.026, 0.039 and 0.22 μM for rat, mice and human leukocytes respectively). Displays anti-inflammatory activity. Orally active.
技术数据 for BAY-X 1005
| 分子量 | 361.43 |
| 公式 | C23H23NO3 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 128253-31-6 |
| PubChem ID | 123723 |
| InChI Key | ZEYYDOLCHFETHQ-JOCHJYFZSA-N |
| Smiles | O=[C@@]([C@H](C4CCCC4)C(C=C3)=CC=C3OCC2=NC1=CC=CC=C1C=C2)O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for BAY-X 1005
参考文献 for BAY-X 1005
参考文献是支持产品生物活性的出版物。
Muller-Peddinghaus et al (1993) BAY X1005, a new inhibitor of leukotriene synthesis: in vivo inflammation pharmacology and pharmacokinetics. J.Pharmacol.Exp.Ther. 267 51 PMID: 8229782
Hatzelmann et al (1994) Mode of action of the leukotriene synthesis (FLAP) inhibitor BAY X 1005: implications for biological regulation of 5-lipoxygenase. Agents Actions 43 64 PMID: 7741044
Fruchtmann et al (1993) In vitro pharmacology of BAY X1005, a new inhibitor of leukotriene synthesis. Agents Actions 38 188 PMID: 8213345
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关键词: BAY-X 1005, BAY-X 1005 supplier, BAY-X1005, 5-lipoxygenase, activating, protein, FLAP, inhibitors, inhibits, leukotriene, synthesis, signaling, signalling, antiinflammatory, 5-LOX, Lipoxygenase, Leukotriene, and, Related, Receptors, 3541, Tocris Bioscience
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