Benidipine hydrochloride

Name: Benidipine hydrochloride
Brand: Tocris Bioscience
SKU: 3934

Cat. No. 3934 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3934 has been discontinued.

View all Non-selective Ca<sub>v</sub> Channels products.

说明： Non-selective Ca_v blocker; also mineralocorticoid receptor antagonist

别名： KW 3049

化学名： (4R)-rel-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester hydrochloride

纯度： ≥99% (HPLC)

说明书

引用文献 (1)

生物活性技术数据说明书参考文献

生物活性 for Benidipine hydrochloride

Orally active antihypertensive agent which displays a wide range of activities in vitro and in vivo. Inhibits L-, N- and T-type Ca²⁺ channels. Also inhibits aldosterone-induced mineralocorticoid receptor activation. Exhibits cardioprotective and antiartherosclerotic effects.

技术数据 for Benidipine hydrochloride

分子量	542.02
公式	C₂₈H₃₁N₃O₆.HCl
储存	Desiccate at RT
纯度	≥99% (HPLC)
CAS Number	91599-74-5
PubChem ID	76968919
InChI Key	SPMJXDRNJQIBTB-IMEZZWDRSA-N
Smiles	CC1=C(C(OC)=O)[C@@H]([C@]2=CC([N+]([O-])=O)=CC=C2)C(C(O[C@H]3CN(CC4=CC=CC=C4)CCC3)=O)=C(C)N1.CC5=C(C(OC)=O)[C@H]([C@]6=CC([N+]([O-])=O)=CC=C6)C(C(O[C@@H]7CN(CC8=CC=CC=C8)CCC7)=O)=C(C)N5.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Benidipine hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Benidipine hydrochloride

参考文献是支持产品生物活性的出版物。

Yao et al (2006) Pharmacological, pharmacokinetic, and clinical properties of benidipine hydrochloride, a novel long-acting calcium channel blocker. J.Pharmacol.Sci. 100 243 PMID: 16565579

Kosaka et al (2010) The L-, N-, T-type triple calcium channel blocker benidipine acts as an antagonist of mineralocorticoid receptor, a member of nuclear receptor family. Eur.J.Pharmacol. 635 49 PMID: 20307534

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关键词: Benidipine hydrochloride, Benidipine hydrochloride supplier, L-type, T-type, N-type, calcium, channels, Ca2+, blockers, inhibitors, inhibits, selective, voltage-gated, voltage-dependent, CaV, mineralocorticoid, receptor, antagonist, KW3049, KW, 3049, Non-selective, Cav, Channels, Mineralocorticoid, Receptor, 3934, Tocris Bioscience

1 篇 Benidipine hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Benidipine hydrochloride 的部分引用包括：

Bhandage et al (2019) Toxoplasma-Induced Hypermigration of Primary Cortical Microglia Implicates GABAergic Signaling. Front Cell Infect Microbiol 9 73 PMID: 30949457