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Bexarotene

Cat. No. 5819 3 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective RXR agonist
别名： LGD 1069
化学名： 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid
纯度： ≥99% (HPLC)
说明书
引用文献 (3)
评论 (1)
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Bexarotene

Bexarotene is a potent and selective RXR agonist (EC50 values are 24, 25 and 33 nM for RXRβ, RXRγ and RXRα, respectively). Exhibits >300-fold selectivity for RXR over RAR receptors. Inhibits tumor cell invasion and migration in vitro, and inhibits metastasis and angiogenesis in mouse models. Also promotes brown adipogenic differentiation and induces brown adipogenic reprogramming from myoblasts.

技术数据 for Bexarotene

分子量 348.48
公式 C24H28O2
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 153559-49-0
PubChem ID 82146
InChI Key NAVMQTYZDKMPEU-UHFFFAOYSA-N
Smiles CC(CCC(C)2C)(C)C1=C2C=C(C)C(C(C3=CC=C(C(O)=O)C=C3)=C)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Bexarotene

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 34.85 100
ethanol 6.97 20 温和加热

制备储备液 for Bexarotene

以下数据基于产品分子量 348.48。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.87 mL 14.35 mL 28.7 mL
5 mM 0.57 mL 2.87 mL 5.74 mL
10 mM 0.29 mL 1.43 mL 2.87 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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参考文献 for Bexarotene

参考文献是支持产品生物活性的出版物。

Boehm et al (1994) Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids. J.Med.Chem. 37 2930 PMID: 8071941

Yen et al (2006) A selective retinoid X receptor agonist bexar. (LGD1069, Targretin) inhibits angiogenesis and metastasis in solid tumours. Br.J.Cancer 94 654 PMID: 16495926

Nie et al (2017) Brown adipogenic reprogramming induced by a small molecule. Cell Rep. 18 624 PMID: 28099842

If you know of a relevant reference for Bexarotene, please let us know.

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关键词: Bexarotene, Bexarotene supplier, retinoid, X, receptors, agonists, agonism, RXR, α, β, γ, alpha, beta, gamma, potent, selective, cancer, metastasis, angiogenesis, LG1069, stem, cells, differentiation, brown, adipocytes, adipogenic, reprogramming, LGD1069, Retinoid, Receptor, Stem, Cell, Reprogramming, 5819, Tocris Bioscience

3 篇 Bexarotene 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Bexarotene 的部分引用包括：

Hebert (2017) Effects of retinoic acid signaling on extraocular muscle myogenic precursor cells in vitro. Exp Cell Res 361 101 PMID: 29017757

McCullough et al (2018) Cell-type-specific interrogation of CeA Drd2 neurons to identify targets for pharmacological modulation of fear extinction. Transl Psychiatry 8 164 PMID: 30135420

J David et al (2022) Retinoid-X receptor agonists increase thyroid hormone competence in lower jaw remodeling of pre-metamorphic Xenopus laevis tadpoles. PLoS One 17 e0266946 PMID: 35417489

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Bexarotene 的评论

平均评分: 4 (Based on 1 Review.)

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CeA Drd2 neurons to identify targets for pharmacological modulation of fear extinction.
By Anonymous on 02/08/2020
分析类型： In Vivo
种属： Mouse
细胞系/组织： Rosa26 fs-TRAP (B6.129S4-Gt(ROSA)26Sortm1(CAG-EGFP/Rpl10a,-birA)Wtp/J)

Bexarotene has limited solubility in water, thus it was dissolved in pure DMSO prior to injection and injected i.p. at 50 mg/kg in a volume of 0.03 ml using an insulin syringe.

PMID: 30135420
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该领域的文献

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Retinoid Receptors Scientific Review

Retinoid Receptors Scientific Review

Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.