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Submit ReviewBGC 20-761
说明： High affinity 5-HT6 antagonist
化学名： 5-Methoxy-N,N-dimethyl-2-phenyl-1H-indole-3-ethanamine
纯度： ≥98% (HPLC)
生物活性 for BGC 20-761
BGC 20-761 is a selective, high affinity 5-HT6 antagonist (Ki = 20 nM). Reverses the amnesic effects of scopolamine (Cat. No. 1414) and enhances memory consolidation in a rat model.
技术数据 for BGC 20-761
| 分子量 | 294.39 |
| 公式 | C19H22N2O |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 17375-63-2 |
| PubChem ID | 6918515 |
| InChI Key | VSGPGYWZVPDDSK-UHFFFAOYSA-N |
| Smiles | CN(CCC2=C(C3=CC=CC=C3)NC1=CC=C(OC)C=C12)C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for BGC 20-761
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 29.44 | 100 | |
| ethanol | 14.72 | 50 |
制备储备液 for BGC 20-761
以下数据基于产品分子量 294.39。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.4 mL | 16.98 mL | 33.97 mL |
| 5 mM | 0.68 mL | 3.4 mL | 6.79 mL |
| 10 mM | 0.34 mL | 1.7 mL | 3.4 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.68 mL |
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产品说明书 for BGC 20-761
参考文献 for BGC 20-761
参考文献是支持产品生物活性的出版物。
Glennon et al (2000) 2-substituted tryptamines: agents with selectivity for 5-HT6 serotonin receptors. J.Med.Chem. 43 1011 PMID: 10715164
Mitchell et al (2006) BGC20-761, a novel tryptamine analog, enhances memory consolidation and reverses scopolamine-induced memory deficit in social and visuospatial memory tasks through a 5-HT6 receptor-mediated mechanism. Neuropharmacology 50 412 PMID: 16298400
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关键词: BGC 20-761, BGC 20-761 supplier, 5ht, 5-hydroxytryptamine, serotonin, 5ht6, high, affinity, ligands, BGC20761, 5-HT6, Receptors, 3326, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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