BI 3231 最新

Cat. No. 8039 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective hydroxysteroid 17β dehydrogenase 13 (HSD17B13) inhibitor

化学名： 1-[[5-(2,4-Difluoro-3-hydroxyphenyl)-1,3,4-thiadiazol-2-yl]methyl]-3-ethyl-5-methyl-2,4(1H,3H)pyrimidinedione

纯度： ≥98% (HPLC)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for BI 3231

BI 3231 is a potent and selective hydroxysteroid 17β dehydrogenase 13 (HSD17B13) inhibitor (IC₅₀ values are 1 nM and 13 nM at hHSD17B13 and mHSD17B13 respectively; K_i = 0.7 nM). Reduces palmitic acid-induced toxicity in hepatocytes. Suitable for use in vivo and in vitro.

许可信息

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BI 3231 probe summary on the SGC website.

技术数据 for BI 3231

分子量	380.37
公式	C₁₆H₁₄F₂N₄O₃S
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	2894848-07-6
PubChem ID	167312378
InChI Key	XKDHFIPNTTUSIA-UHFFFAOYSA-N
Smiles	O=C1C(C)=CN(CC2=NN=C(C3=C(F)C(O)=C(F)C=C3)S2)C(N1CC)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BI 3231

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	3.8	10 温和加热

制备储备液 for BI 3231

以下数据基于产品分子量 380.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.1 mM	26.29 mL	131.45 mL	262.9 mL
0.5 mM	5.26 mL	26.29 mL	52.58 mL
1 mM	2.63 mL	13.15 mL	26.29 mL
5 mM	0.53 mL	2.63 mL	5.26 mL

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产品说明书 for BI 3231

分析证书/产品说明书

化学品安全技术说明书

参考文献 for BI 3231

参考文献是支持产品生物活性的出版物。

Thamm et al (2023) Discovery of a novel potent and selective HSD17B13 inhibitor, BI-3231, a well-characterized chemical probe available for open science. J.Med.Chem. 66 2832 PMID: 36727857

If you know of a relevant reference for BI 3231, please let us know.

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关键词: BI 3231, BI 3231 supplier, BI3231, hydroxysteroid, 17beta, 17b, dehydrogenase, 13, HSD17B13, inhibitor, inhibits, inhibitors, potent, selective, hepatocytes, NASH, non, alcoholic, steatohepatitis, Other, Dehydrogenases, 8039, Tocris Bioscience

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