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BI 9321

Cat. No. 6665 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Nuclear receptor-binding SET domain (NSD) 3 antagonist; selectively binds PWWP1 domain
化学名： (4-(5-(7-Fluoroquinolin-4-yl)-1-methyl-1H-imidazol-4-yl)-3,5-dimethylphenyl)methanamine trihydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BI 9321

BI 9321 is a nuclear receptor-binding SET domain (NSD) 3 antagonist (IC50 = 1.2 μM). Selectively binds the PWWP1 domain of NSD3 (Kd = 166 nM). Antagonizes the interaction of H3 with NSD3-PWWP1 in U2OS cells.

许可信息

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BI 9321 probe summary on the SGC website.

技术数据 for BI 9321

分子量 469.81
公式 C22H21FN4.3HCl
储存 Desiccate at RT
纯度 ≥98% (HPLC)
CAS Number 2387510-87-2
InChI Key DCDXMBVQCRHZMW-UHFFFAOYSA-N
Smiles CN1C=NC(C2=C(C=C(C=C2C)CN)C)=C1C3=C4C=CC(F)=CC4=NC=C3.Cl.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BI 9321

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 46.98 100
DMSO 46.98 100

制备储备液 for BI 9321

以下数据基于产品分子量 469.81。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.13 mL 10.64 mL 21.29 mL
5 mM 0.43 mL 2.13 mL 4.26 mL
10 mM 0.21 mL 1.06 mL 2.13 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

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参考文献 for BI 9321

参考文献是支持产品生物活性的出版物。

Böttcher et al (2019) Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3. Nat.Chem.Biol. 15 822 PMID: 31285596

If you know of a relevant reference for BI 9321, please let us know.

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关键词: BI 9321, BI 9321 supplier, BI9321, nuclear, receptor-binding, SET, domain, 3, NSD3, antagonists, antagonism, lysine, methyltransferases, Other, Lysine, Methyltransferases, 6665, Tocris Bioscience

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