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Submit ReviewBIO 1211
说明： Selective α4β1 (VLA-4) inhibitor
纯度： ≥95% (HPLC)
生物活性 for BIO 1211
BIO 1211 is a selective, high affinity α4β1 (Very Late Antigen 4; VLA-4) inhibitor; displays 200-fold selectivity for the activated form of α4β1 (KD = 70 pM; IC50 = 0.004 μM). Selective for α4β1 over a range of other integrins (IC50 >100 μM for α1β1, α5β1 and α6β1).
技术数据 for BIO 1211
| 分子量 | 708.8 |
| 公式 | C36H48N6O9 |
| 序列 | MPUPA-LDVP |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 187735-94-0 |
| PubChem ID | 9961766 |
| InChI Key | NVVGCQABIHSJSQ-KFZSMJGVSA-N |
| Smiles | O=C(CC2=CC=C(NC(NC3=CC=CC=C3C)=O)C=C2)N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@@H](C)C)C(N1CCC[C@H]1[C@@](O)=O)=O)=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for BIO 1211
| 溶解性 | Soluble to 2 mg/ml in water |
产品说明书 for BIO 1211
参考文献 for BIO 1211
参考文献是支持产品生物活性的出版物。
Chen et al (1999) Multiple activation sites of integrin α4β1 detected through their different affinities for a small molecule ligand. J.Biol.Chem. 274 13167 PMID: 10224072
Lin et al (1999) Selective, tight-binding inhibitors of integrin α4β1 that inhibit allergic airway responses. J.Med.Chem. 42 920 PMID: 10072689
Muro et al (2009) Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid: an orally active, selective very late antigen-4 antagonist. J.Med.Chem. 52 7974 PMID: 19891440
If you know of a relevant reference for BIO 1211, please let us know.
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关键词: BIO 1211, BIO 1211 supplier, Selective, high, affinity, α4β1, a4b1, alpha4beta1, very, late, antigen, VLA-4, VLA4, inhibitors, inhibits, integrins, BIO1211, Integrins, Cell, Adhesion, Molecules, 3910, Tocris Bioscience
3 篇 BIO 1211 的引用文献
引用文献是使用了 Tocris 产品的出版物。 BIO 1211 的部分引用包括：
Lujan et al (2015) Early reprogramming regulators identified by prospective isolation and mass cytometry. Nature 521 352 PMID: 25830878
Fujita et al (2014) The binding of monomeric C-reactive protein (mCRP) to Integrins αvβ3 and α4β1 is related to its pro-inflammatory action. PLoS One 9 e93738 PMID: 24695572
Hanna et al (2017) Modulation of interactions of neuroblastoma cell lines with extracellular matrix proteins affects their sensitivity to treatment with the anti-GD2 ganglioside antibody 14G2a. Int J Oncol 50 1899-1914 PMID: 28393238
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Angiogenesis in Cancer Poster
This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.
