BMS 182874 hydrochloride

Name: BMS 182874 hydrochloride
Brand: Tocris Bioscience
SKU: 1441

Cat. No. 1441 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1441 has been discontinued.

View all ET<sub>A</sub> Receptors products.

说明： Highly selective, orally active non-peptide ET_A antagonist

化学名： 5-(Dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide hydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献 (2)

生物活性技术数据说明书参考文献

生物活性 for BMS 182874 hydrochloride

BMS 182874 hydrochloride is a potent, selective and competitive non-peptide endothelin ET_A receptor antagonist (K_i = 48 nM). Displays > 1000-fold selectivity over ET_B receptors. Inhibits ET-1-induced pressor response following oral or intravenous administration in vivo. Inhibits ET-1-induced longitudinal muscle contraction in the mouse colon in vitro.

许可信息

Sold with the permission of Bristol-Myers Squibb Company, subject to U.S. Patent No. 5,378,715 and other US and foreign patents

技术数据 for BMS 182874 hydrochloride

分子量	381.88
公式	C₁₇H₁₉N₃O₃S.HCl
储存	Store at RT
纯度	≥98% (HPLC)
CAS Number	1215703-04-0
PubChem ID	56972163
InChI Key	UZZFRNZGYDOBAO-UHFFFAOYSA-N
Smiles	Cl.CN(C)C1=C2C=CC=C(C2=CC=C1)S(=O)(=O)NC1=C(C)C(C)=NO1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for BMS 182874 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for BMS 182874 hydrochloride

参考文献是支持产品生物活性的出版物。

Khan et al (2006) Pharmacological characterization of endothelin receptors-mediated contraction in the mouse isolated proximal and distal colon. Br.J.Pharmacol. 147 607 PMID: 16432510

Stein et al (1994) The discovery of sulfonamide endothelin antagonists and the development of the orally active ETA antagonist 5-(Dimethylamino)-N-(3,4-dimethyl-5-isoazolyl)-1-naphthalenesulfonamide. J.Med.Chem. 37 329 PMID: 8308857

Webb et al (1995) BMS-182874 is a selective, nonpeptide endothelin ET_A receptor antagonist. J.Pharmacol.Exp.Ther. 272 1124 PMID: 7891325

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关键词: BMS 182874 hydrochloride, BMS 182874 hydrochloride supplier, selective, orally, active, non-peptide, ETA, antagonists, receptors, endothelin, BMS182874, hydrochloride, Endothelin, Receptors, 1441, Tocris Bioscience

2 篇 BMS 182874 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BMS 182874 hydrochloride 的部分引用包括：

Yuan et al (2015) Endothelial cells enhance the migration of bovine meniscus cells. Arthritis Rheumatol 67 182 PMID: 25307081

Khan et al (2006) Pharmacological characterization of endothelin receptors-mediated contraction in the mouse isolated proximal and distal colon. Br J Pharmacol 147 607 PMID: 16432510