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Submit ReviewBMS 453
说明： Synthetic retinoid and RARβ agonist; also RARα and RARγ antagonist
别名： BMS 189453
化学名： 4-[(1E)-2-(5,6-Dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]-benzoic acid
纯度： ≥98% (HPLC)
生物活性 for BMS 453
BMS 453 is a synthetic retinoid. Retinoic acid receptor β (RARβ) agonist in vivo; RARα and RARγ antagonist in vitro. Inhibits breast cell proliferation by inducing active transforming growth factor β (TGFβ) and causes G1 arrest.
技术数据 for BMS 453
| 分子量 | 380.48 |
| 公式 | C27H24O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 166977-43-1 |
| PubChem ID | 9875424 |
| InChI Key | VUODRPPTYLBGFM-CMDGGOBGSA-N |
| Smiles | CC(CC=C3C4=CC=CC=C4)(C)C(C3=C2)=CC=C2/C=C/C1=CC=C(C(O)=O)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for BMS 453
参考文献 for BMS 453
参考文献是支持产品生物活性的出版物。
Chen et al (1995) RAR-specific agonist/antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage-independent cell proliferation. EMBO J. 14 1187 PMID: 7720709
Yang et al (2001) The retinoic acid receptor antagonist, BMS543, inhibits normal breast cell growth by inducing active TGFB and causing cell cycle arrest. Oncogene 20 8025 PMID: 11753686
Monteiro et al (2009) Commitment of mouse embryonic stem cells to the adipocyte lineage requires retinoic acid receptor beta and active GSK3. Stem Cells Dev. 18 457 PMID: 18690793
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关键词: BMS 453, BMS 453 supplier, BMS453, retinoic, acid, receptors, RARβ, RARα, RARγ, RARalpha, RARbeta, RARgamma, RARa, RARb, RARg, agonists, antagonists, BMS189453, BMS, 189453, Retinoic, Acid, Receptors, 3409, Tocris Bioscience
3 篇 BMS 453 的引用文献
引用文献是使用了 Tocris 产品的出版物。 BMS 453 的部分引用包括：
Mizee et al (2013) Retinoic acid induces blood-brain barrier development. J Neurosci 33 1660 PMID: 23345238
Wahl et al (2018) Transcriptome analysis of Xenopus orofacial tissues deficient in retinoic acid receptor function. BMC Genomics 19 795 PMID: 30390632
Naylor et al (2016) BMP and retinoic acid regulate anterior-posterior patterning of the non-axial mesoderm across the dorsal-ventral axis. Nat Commun 7 12197 PMID: 27406002
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Retinoid Receptors Scientific Review
Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.