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Submit ReviewBMS 564929
说明： Highly potent and muscle-selective androgen receptor (AR) agonist
化学名： 2-Chloro-3-methyl-4-[(7R,7aS)-tetrahydro-7-hydroxy-1,3-dioxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl]benzonitrile
纯度： ≥98% (HPLC)
生物活性 for BMS 564929
BMS 564929 is a highly potent and selective androgen receptor (AR) agonist (EC50 = 0.44 nM). Exhibits selectivity for ARs over estrogen, glucocorticoid and mineralocorticoid receptors and no significant binding to steroid hormone binding globulin or aromatase. Also exhibits selectivity for muscle over prostate ARs. Active in vivo and orally bioavailable.
技术数据 for BMS 564929
| 分子量 | 305.72 |
| 公式 | C14H12ClN3O3 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 627530-84-1 |
| PubChem ID | 49823417 |
| InChI Key | KEJORAMIZFOODM-UHFFFAOYSA-N |
| Smiles | [H][C@@]12[C@H](O)CCN1C(=O)N(C2=O)C1=CC=C(C#N)C(Cl)=C1C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for BMS 564929
参考文献 for BMS 564929
参考文献是支持产品生物活性的出版物。
Ostrowski et al (2007) Pharmacological and X-ray structural characterization of a novel selective androgen receptor modulator: potent hyperanabolic stimulation of skeletal muscle with hypostimulation of prostate in rats. Endocrinology 148 4
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关键词: BMS 564929, BMS 564929 supplier, BMS564929, highly, potent, muscle-selective, androgen, receptor, AR, agonist, orally, bioavailable, Androgen, Receptor, 5274, Tocris Bioscience
1 篇 BMS 564929 的引用文献
引用文献是使用了 Tocris 产品的出版物。 BMS 564929 的部分引用包括：
Jennifer J et al (2020) Predicting the Activation of the Androgen Receptor by Mixtures of Ligands Using Generalized Concentration Addition. Toxicol Sci 177 466-475 PMID: 32726424
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