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BMS 564929

Cat. No. 5274 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Highly potent and muscle-selective androgen receptor (AR) agonist
化学名： 2-Chloro-3-methyl-4-[(7R,7aS)-tetrahydro-7-hydroxy-1,3-dioxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl]benzonitrile
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BMS 564929

BMS 564929 is a highly potent and selective androgen receptor (AR) agonist (EC50 = 0.44 nM). Exhibits selectivity for ARs over estrogen, glucocorticoid and mineralocorticoid receptors and no significant binding to steroid hormone binding globulin or aromatase. Also exhibits selectivity for muscle over prostate ARs. Active in vivo and orally bioavailable.

技术数据 for BMS 564929

分子量 305.72
公式 C14H12ClN3O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 627530-84-1
PubChem ID 49823417
InChI Key KEJORAMIZFOODM-UHFFFAOYSA-N
Smiles [H][C@@]12[C@H](O)CCN1C(=O)N(C2=O)C1=CC=C(C#N)C(Cl)=C1C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BMS 564929

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 30.57 100

制备储备液 for BMS 564929

以下数据基于产品分子量 305.72。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.27 mL 16.35 mL 32.71 mL
5 mM 0.65 mL 3.27 mL 6.54 mL
10 mM 0.33 mL 1.64 mL 3.27 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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参考文献 for BMS 564929

参考文献是支持产品生物活性的出版物。

Ostrowski et al (2007) Pharmacological and X-ray structural characterization of a novel selective androgen receptor modulator: potent hyperanabolic stimulation of skeletal muscle with hypostimulation of prostate in rats. Endocrinology 148 4

If you know of a relevant reference for BMS 564929, please let us know.

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关键词: BMS 564929, BMS 564929 supplier, BMS564929, highly, potent, muscle-selective, androgen, receptor, AR, agonist, orally, bioavailable, Androgen, Receptor, 5274, Tocris Bioscience

1 篇 BMS 564929 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BMS 564929 的部分引用包括：

Jennifer J et al (2020) Predicting the Activation of the Androgen Receptor by Mixtures of Ligands Using Generalized Concentration Addition. Toxicol Sci 177 466-475 PMID: 32726424

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