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Submit ReviewBMS 566419
说明： Inosine monophosphatase dehydrogenase (IMPDH) inhibitor
化学名： N-[1-[6-(4-Ethyl-1-piperazinyl)-3-pyridinyl]-1-methylethyl]-2-fluoro-9,10-dihydro-9-oxo-3-acridinecarboxamide
纯度： ≥98% (HPLC)
生物活性 for BMS 566419
BMS 566419 is a potent inosine monophosphate dehydrogenase (IMPDH) inhibitor (IC50 = 17 nM). Inhibits proliferation of human T-lymphoblasts and PBMCs in vitro. Reduces paw swelling in a rat adjuvant arthritis model. Orally available.
技术数据 for BMS 566419
| 分子量 | 487.57 |
| 公式 | C28H30FN5O2 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 566161-24-8 |
| PubChem ID | 9913339 |
| InChI Key | XEVJUIZOZCFECP-UHFFFAOYSA-N |
| Smiles | O=C2C3=C(C=C(C(NC(C)(C)C4=CC=C(N5CCN(CC)CC5)N=C4)=O)C(F)=C3)NC1=CC=CC=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for BMS 566419
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| 1eq. HCl | 24.38 | 50 | |
| DMSO | 48.76 | 100 |
制备储备液 for BMS 566419
以下数据基于产品分子量 487.57。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.05 mL | 10.25 mL | 20.51 mL |
| 5 mM | 0.41 mL | 2.05 mL | 4.1 mL |
| 10 mM | 0.21 mL | 1.03 mL | 2.05 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.41 mL |
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产品说明书 for BMS 566419
参考文献 for BMS 566419
参考文献是支持产品生物活性的出版物。
Watterson et al (2007) Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419). J.Med.Chem. 50 3730 PMID: 17585753
If you know of a relevant reference for BMS 566419, please let us know.
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关键词: BMS 566419, BMS 566419 supplier, BMS566419, inosine, monophosphate, dehydrogenase, inhibitors, inhibits, IMPDH, immunosuppressant, anti-inflammatory, rheumatoid, arthritis, orally, available, potent, Other, Dehydrogenases, 5492, Tocris Bioscience
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