BMY 14802 hydrochloride

Name: BMY 14802 hydrochloride
Brand: Tocris Bioscience
SKU: 1440

Cat. No. 1440 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1440 has been discontinued.

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说明： Sigma antagonist. Antipsychotic agent

化学名： α-(4-Fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol hydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献 (2)

生物活性技术数据说明书参考文献

生物活性 for BMY 14802 hydrochloride

BMY 14802 hydrochloride is a potent sigma receptor antagonist (IC₅₀ = 112 nM) with modest to weak affinity for 5-HT_1A and α₁ receptors. Antipsychotic following oral administration and acts via indirect modulation of central dopaminergic systems.

许可信息

Sold with the permission of Bristol-Myers Squibb Company

技术数据 for BMY 14802 hydrochloride

分子量	384.86
公式	C₁₈H₂₂F₂N₄O.HCl
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	105565-55-7
PubChem ID	3086514
InChI Key	NIBVEFRJDFVQLM-UHFFFAOYSA-N
Smiles	Cl.OC(CCCN1CCN(CC1)C1=NC=C(F)C=N1)C1=CC=C(F)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for BMY 14802 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for BMY 14802 hydrochloride

参考文献是支持产品生物活性的出版物。

Taylor et al (1993) A role for sigma binding in the antipsychotic profile of BMY 14802? NIDA Res.Monogr. 133 125 PMID: 8232511

Yevich et al (1992) Synthesis and biological characterization of α-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and analogues as potential atypical antipsychotic agents. J.Med.Chem. 35 4516 PMID: 1361578

Zhang et al (1993) Further characterization of the effects of BMY 14802 on DA neuronal activity. Synapse 15 276 PMID: 7908761

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关键词: BMY 14802 hydrochloride, BMY 14802 hydrochloride supplier, σ, sigma, antagonists, Antipsychotic, agent, General, Receptors, BMY14802, Sigma-Related, 1440, Tocris Bioscience

2 篇 BMY 14802 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BMY 14802 hydrochloride 的部分引用包括：

Bhide et al (2013) The effects of BMY-14802 against L-DOPA- and DA agonist-induced dyskinesia in the hemiparkinsonian rat. Psychopharmacology (Berl) 227 533 PMID: 23389756

Paquette et al (2008) σ ligands, but not N-MthD.-aspartate antagonists, reduce levodopa-induced dyskinesias. Reprod Biol Endocrinol 19 111 PMID: 18281903