BMY 7378 dihydrochloride

Name: BMY 7378 dihydrochloride
Brand: Tocris Bioscience
SKU: 1006

Cat. No. 1006 6 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1006 has been discontinued.

View all Adrenergic α<sub>1</sub> Receptors products.

说明： Selective α_1D antagonist

化学名： 8-[2-[4-(methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione dihydrochloride

说明书

引用文献 (6)

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for BMY 7378 dihydrochloride

BMY 7378 dihydrochloride is a 5-HT_1A partial agonist and high affinity α_1D adrenoceptor antagonist (K_i values are 2, 800 and 600 nM at cloned rat α_1D, rat α_1A and hamster α_1B receptors, respectively).

技术数据 for BMY 7378 dihydrochloride

分子量	458.42
公式	C₂₂H₃₁N₃O₃.2HCl
储存	Store at RT
CAS Number	21102-95-4
PubChem ID	24744861
InChI Key	HZRPUQURUAXOHB-UHFFFAOYSA-N
Smiles	O=C1CC4(CCCC4)CC(N1CCN(CC3)CCN3C2=CC=CC=C2OC)=O.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for BMY 7378 dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for BMY 7378 dihydrochloride

参考文献是支持产品生物活性的出版物。

Gruel and Glaser (1992) The putative 5-HT_1A receptor antagonists NAN-190 and BMY 7378 are partial agonists in the rat dorsal raphe nucleus in vitro. Eur.J.Pharmacol. 211 211 PMID: 1535319

Piascik et al (1995) The specific contribution of the novel alpha-1D adrenoceptor to the contraction of vascular smooth muscle. J.Pharmacol.Exp.Ther. 275 1583 PMID: 8531132

Sharp et al (1990) Further investigation of the in vivo pharmacological properties of the putative 5-HT_1A antagonist, BMY 7378. Eur.J.Pharmacol. 176 331 PMID: 1970304

Yang and Endoh (1997) Pharmacological evidence for β_1D-adrenoceptors in the rabbit ventricular myocardium: analysis with BMY 7378. Br.J.Pharmacol 122 1541 PMID: 9422797

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Adrenergic α₁ Receptor Antagonists

关键词: BMY 7378 dihydrochloride, BMY 7378 dihydrochloride supplier, Selective, α1D-adrenoceptor, alpha1D-adrenoceptor, a1d-adrenoceptor, α1d-adrenergic, alpha1d-adrenergic, a1d-adrenergic, antagonist, 5-HT1A, partial, agonists, Receptors, Serotonin, BMY7378, dihydrochloride, Adrenergic, Alpha-1, 1006, Tocris Bioscience

6 篇 BMY 7378 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BMY 7378 dihydrochloride 的部分引用包括：

Grisanti et al (2011) α1-adrenergic receptors positively regulate Toll-like receptor cytokine production from human monocytes and macrophages. J Pharmacol Exp Ther 338 648 PMID: 21571945

Gadgaard & Jensen (2020) Functional characterization of 5-HT_1A and 5-HT_1B serotonin receptor signaling through G-protein-activated inwardly rectifying K⁺ channels in a fluorescence-based membrane potential assay. Biochem Pharmacolg 175 PMID: 32088264

Kahn et al (2016) The anti-hypertensive drug pra. inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway. EMBO Mol Med 8 511 PMID: 27138566

Song et al (2010) Multiple alpha1-adrenergic receptor subtypes support synergistic stimulation of vasopressin and oxyt. release by ATP and phenylephrine. Am J Physiol Regul Integr Comp Physiol 299 R1529 PMID: 20881098

Lee et al (2010) Characterisation of the expression of NMDA receptors in human astrocytes. PLoS One 5 e14123 PMID: 21152063

Atkins et al (2010) Circadian integration of glutamatergic signals by little SAAS in novel suprachiasmatic circuits. PLoS One 5 e12612 PMID: 20830308