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Bobcat339

Cat. No. 6977 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Ten-eleven translocation methylcytosine dioxygenase (TET) inhibitor
化学名： 4-Amino-1-[1,1'-biphenyl]-3-yl-5-chloro-2(1H)-pyrimidinone
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Bobcat339

Bobcat339 is a selective cytosine-based inhibitor of ten-eleven translocation methylcytosine dioxygenase (TET) (IC50 values are 33 and 73 μM for TET1 and TET2, respectively). Bobcat339 reduces DNA 5-hydroxymethylcytosine (5hmC) levels in cells without inhibiting the DNA methyltransferase DNMT3a.

技术数据 for Bobcat339

分子量 297.74
公式 C16H12ClN3O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2280037-51-4
PubChem ID 138319673
InChI Key QMGYGOOYCNTEQO-UHFFFAOYSA-N
Smiles NC1=NC(N(C2=CC(C3=CC=CC=C3)=CC=C2)C=C1Cl)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Bobcat339

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 29.77 100
ethanol 1.49 5

制备储备液 for Bobcat339

以下数据基于产品分子量 297.74。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.36 mL 16.79 mL 33.59 mL
5 mM 0.67 mL 3.36 mL 6.72 mL
10 mM 0.34 mL 1.68 mL 3.36 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

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参考文献 for Bobcat339

参考文献是支持产品生物活性的出版物。

Chua et al (2019) Cytosine-based TET enzyme inhibitors. ACS Med.Chem.Lett. 10 180 PMID: 30783500

Blecua et al (2020) The DNA methylation landscape of hematological malignancies: an update. Mol.Oncol. 14 1616 PMID: 32526054

If you know of a relevant reference for Bobcat339, please let us know.

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关键词: Bobcat339, Bobcat339 supplier, Bobcat339, inhibitors, inhibits, hematopoietic, hematopoiesis, haematopoietic, malignancies, leukemia, lymphoma, methylation, ten-eleven, translocation, methylcytosine, dioxygenase, TET, Other, Oxygenases/Oxidases, 6977, Tocris Bioscience

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