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Discontinued Product
3221 has been discontinued.
View all Nicotinic Receptors (Non-selective) products.
说明： Orthosteric neuronal nAChR antagonist
化学名： 1,1'-(1,12-Dodecanediyl)bis[3-methylpyridinium] dibromide
纯度： ≥98% (HPLC)
生物活性 for bPiDDB
bPiDDB is an orthosteric neuronal nicotinic acetylcholine receptor (nAChR) antagonist (IC50 values are 0.17, 0.25, 0.4, 4.8, 6.5, 8.2, 20 and 34 μM at α3β4, α1β1εδ, α3β4β3, α6β4β3, α7, α4β2, α3β2β3 and α6/3β2β3 receptors respectively). Attenuates nicotine-evoked dopamine release from the ventral tegmental area in vivo (IC50 = 0.2 nM) and reduces nicotine self-administration in rats. Brain penetrant.
技术数据 for bPiDDB
| 分子量 | 514.38 |
| 公式 | C24H38Br2N2 |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 525596-66-1 |
| PubChem ID | 9983961 |
| InChI Key | NNPBJCAIRCFEFZ-UHFFFAOYSA-L |
| Smiles | CC1=CC=C[N+](CCCCCCCCCCCC[N+]2=CC(C)=CC=C2)=C1.[Br-].[Br-] |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for bPiDDB
参考文献 for bPiDDB
参考文献是支持产品生物活性的出版物。
Dwoskin et al (2008) N,N'alkane-diyl-bis-3-picoliniums as nicotinic receptor antagonists: Inhibition of nicotine-evoked DA release and hyperactivity. J.Pharmacol.Exp.Ther. 326 563 PMID: 18460644
Rahman et al (2008) Region-specific effects of the N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide on nicotine-induced increase in extracellular DA in vivo. Br.J.Pharmacol. 153 792 PMID: 18059317
Ayers et al (2002) Bis-azaaromatic quaternary ammonium analogues: ligands for α4β2* and β7* subtypes of neuronal nicotinic receptors Bioorg.Med.Chem.Letts. 12 3067
关键词: bPiDDB, bPiDDB supplier, bPiDDB, nicotinic, acetylcholine, receptors, nachrs, orthosteric, antagonists, a3b4, alpha3beta4, α3β4, brain, penetrant, Nicotinic, Receptors, (Non-selective), 3221, Tocris Bioscience
1 篇 bPiDDB 的引用文献
引用文献是使用了 Tocris 产品的出版物。 bPiDDB 的部分引用包括：
Holt et al (2015) Pharmacologically distinct nicotinic acetylcholine receptors drive efferent-mediated excitation in calyx-bearing vestibular afferents. J Cell Biol 35 3625 PMID: 25716861
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.