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BPTES

Cat. No. 5301 3 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective allosteric glutaminase (GLS1) inhibitor
化学名： N,N'-[Thiobis(2,1-ethanediyl-1,3,4-thiadiazole-5,2-diyl)]bisbenzeneacetamide
纯度： ≥95% (HPLC)
说明书
引用文献 (3)
评论 (1)
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BPTES

BPTES is an allosteric glutaminase (GLS1) inhibitor (IC50 = 3.3 μM). Selective for GLS1 over GLS2 and γ-glutamyl transpeptidase. Induces cell death of P493 human lymphoma B cells in vitro and reduces tumor volume of P493 cell xenografts in mice.

技术数据 for BPTES

分子量 524.68
公式 C24H24N6O2S3
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 314045-39-1
PubChem ID 3372016
InChI Key MDJIPXYRSZHCFS-UHFFFAOYSA-N
Smiles O=C(NC2=NN=C(CCSCCC4=NN=C(S4)NC(CC3=CC=CC=C3)=O)S2)CC1=CC=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BPTES

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 10.49 20

制备储备液 for BPTES

以下数据基于产品分子量 524.68。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 9.53 mL 47.65 mL 95.3 mL
1 mM 1.91 mL 9.53 mL 19.06 mL
2 mM 0.95 mL 4.76 mL 9.53 mL
10 mM 0.19 mL 0.95 mL 1.91 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Dilution Calculator

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参考文献 for BPTES

参考文献是支持产品生物活性的出版物。

Le et al (2012) Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell.Metab. 15 110 PMID: 22225880

Shukla et al (2012) Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors. J.Med.Chem. 55 10551 PMID: 23151085

DeLaBarre et al (2011) Full-length human glutaminase in complex with an allosteric inhibitor. Biochemistry 50 10764 PMID: 22049910

If you know of a relevant reference for BPTES, please let us know.

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关键词: BPTES, BPTES supplier, allosteric, glutaminases, gls1, inhibitors, inhibits, selective, Glutaminase, 5301, Tocris Bioscience

3 篇 BPTES 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BPTES 的部分引用包括：

Santosh et al (2021) The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism. Cell Rep 34 108869 PMID: 33730581

Ryan M et al (2020) Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development. Cell Rep 30 2889-2899.e6 PMID: 32130894

Ryan M et al (2023) miRNA-1 promotes acute myeloid leukemia cell pathogenesis through metabolic regulation. Front Genet 14 1192799 PMID: 37229187

您是否知道使用了 Tocris BPTES 的优秀论文？ 请告知我们.

BPTES 的评论

平均评分: 4 (Based on 1 Review.)

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GLS inhibition.
By Anonymous on 09/20/2018
种属： Human

incubation, slight effect

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