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说明： HDAC5 and HDAC9 inhibitor
化学名： 5-Chloro-7-[(4-ethyl-1-piperazinyl)-3-pyridinylmethyl]-8-quinolinol
纯度： ≥98% (HPLC)
生物活性 for BRD 4354
BRD 4354 is a HDAC5 and HDAC9 inhibitor (IC50 values are 0.85 and 1.88 μM, respectively). Also weakly inhibits HDAC4, HDAC6, HDAC7 and HDAC8 (IC50 values are 3.88 - 13.8 μM). Exhibits >20-fold selectivity for HDAC5/9 over HDAC1/2/3.
技术数据 for BRD 4354
| 分子量 | 382.89 |
| 公式 | C21H23ClN4O |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 315698-07-8 |
| PubChem ID | 3516032 |
| InChI Key | XAFSFXYJOJWLJD-UHFFFAOYSA-N |
| Smiles | CCN1CCN(C(C2=C(C3=C(C(Cl)=C2)C=CC=N3)O)C4=CN=CC=C4)CC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for BRD 4354
参考文献 for BRD 4354
参考文献是支持产品生物活性的出版物。
Boskovic et al (2016) Inhibition of zinc-dependent histone deacetylases with a chemically triggered electrophile. ACS Chem.Biol. 11 1844 PMID: 27064299
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关键词: BRD 4354, BRD 4354 supplier, BRD4354, HDAC5, HDAC9, selective, histone, deacetylases, inhibitors, inhibits, Class, II, HDACs, 6010, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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