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Submit ReviewBRD 4770
说明： G9a inhibitor and S-adenosyl methionine mimetic; cell permeable
化学名： Methyl-2-(benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylate
纯度： ≥98% (HPLC)
生物活性 for BRD 4770
BRD 4770 is a G9a inhibitor and S-adenosyl methionine (SAM) mimetic. Inhibits methylation of H3K9 (EC50 ~ 5 μM) and induces senescence in PANC-1 cells. Induces ATM activation without DNA damage. Cell permeable.
技术数据 for BRD 4770
| 分子量 | 413.47 |
| 公式 | C25H23N3O3 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1374601-40-7 |
| PubChem ID | 72193870 |
| InChI Key | UCGWYCMPZXDHNR-UHFFFAOYSA-N |
| Smiles | COC(C1=CC=C2N(C(NC(C3=CC=CC=C3)=O)=NC2=C1)CCCC4=CC=CC=C4)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for BRD 4770
参考文献 for BRD 4770
参考文献是支持产品生物活性的出版物。
Yuan et al (2012) A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinoma. ACS Chem.Biol. 7 1152 PMID: 22536950
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关键词: BRD 4770, BRD 4770 supplier, BRD4770, G9a, inhibitors, inhibits, EHMT2, euchromatin, histone, methyltransferase, 2, KMT1C, cell, permeable, Lysine, Methyltransferases, G9a/GLP, 6282, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Epigenetics in Cancer Poster
This poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.