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Submit ReviewBRD 9757
说明： Potent and selective HDAC6 inhibitor
化学名： N-Hydroxy-1-cyclopentene-1-carboxamide
纯度： ≥98% (HPLC)
生物活性 for BRD 9757
BRD 9757 is a potent and selective HDAC6 inhibitor (IC50 = 30 nM). Displays selectivity for HDAC6 over Class I HDACS (>20-fold) and Class II HDACs (>400-fold).
技术数据 for BRD 9757
| 分子量 | 127.14 |
| 公式 | C6H9NO2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1423058-85-8 |
| PubChem ID | 71655802 |
| InChI Key | RYYGSXXWQSXKRP-UHFFFAOYSA-N |
| Smiles | ONC(C1=CCCC1)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for BRD 9757
参考文献 for BRD 9757
参考文献是支持产品生物活性的出版物。
Wagner et al (2013) Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif. J.Med.Chem. 56 1772 PMID: 23368884
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关键词: BRD 9757, BRD 9757 supplier, BRD9757, potent, selective, HDAC6, inhibitors, inhibits, Class, II, HDACs, 6040, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.
Epigenetics in Cancer Poster
This poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.
Rheumatoid Arthritis Poster
Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.