Bretazenil

Discontinued Product

3568 has been discontinued.

View all GABA<sub>A</sub> Receptors products.
说明: Benzodiazepine partial agonist
别名: Ro 16-6028
化学名: (13aS)-8-Bromo-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid 1,1-dimethylethyl ester
纯度: ≥98% (HPLC)
说明书
引用文献
评论
文献 (2)

生物活性 for Bretazenil

Bretazenil is a partial agonist at the GABAA benzodiazepine site (EC50 = 10 nM at α1β1γ2 receptors). Displays anticonvulsive activity in vivo.

技术数据 for Bretazenil

分子量 418.28
公式 C19H20BrN3O3
储存 Desiccate at +4°C
纯度 ≥98% (HPLC)
CAS Number 84379-13-5
PubChem ID 107926
InChI Key LWUDDYHYYNNIQI-ZDUSSCGKSA-N
Smiles O=C(N4[C@]([H])3CCC4)C1=C(Br)C=CC=C1N2C3=C(C(OC(C)(C)C)=O)N=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Bretazenil

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参考文献 for Bretazenil

参考文献是支持产品生物活性的出版物。

Rundfeldt et al (1995) Anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. Comparison of D.pam, bretazenil and abecarnil. J.Pharmacol.Exp.Ther. 275 693 PMID: 7473156

Munro et al (2008) Comparison of the novel subtype-selective GABAA receptor-positive allosteric modulator NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile] with D.pam, zolpidem, bretazenil, and gaboxadol in rat models of i J.Pharmacol.Exp.Ther. 327 969 PMID: 18791060

Puia et al (1992) Molecular mechanisms of the partial allosteric modulatory effects of bretazenil at γ-aminobutyric acid type A receptor. Proc.Natl.Acad.Sci. USA Neurobiology 89 3620

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关键词: Bretazenil, Bretazenil supplier, benzodiazepines, partial, agonists, GABAA, receptors, Ro16-6028, Ro, 16-6028, Receptors, 3568, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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