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Brivaracetam

Cat. No. 7271 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： SV2A ligand; antiepileptic
化学名： (αS,4R)-α-Ethyl-2-oxo-4-propyl-1-pyrrolidineacetamide
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Brivaracetam

Brivaracetam is an antiepileptic compound that is a ligand for synaptic vesicle glycoprotein 2A (SV2A; Kd = 50 nM for human SV2A in vitro). Brivaracetam displays selectivity for SV2A at 10 μM, against a panel of 55 receptors, enzymes, ion channels and transporters. In mice, Brivaracetam protects against clonic audiogenic seizures.

技术数据 for Brivaracetam

分子量 212.29
公式 C11H20N2O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 357336-20-0
PubChem ID 9837243
InChI Key MSYKRHVOOPPJKU-BDAKNGLRSA-N
Smiles CCC[C@H]1CN(C(C1)=O)[C@H](C(N)=O)CC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Brivaracetam

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 21.23 100
water 21.23 100

制备储备液 for Brivaracetam

以下数据基于产品分子量 212.29。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.71 mL 23.55 mL 47.11 mL
5 mM 0.94 mL 4.71 mL 9.42 mL
10 mM 0.47 mL 2.36 mL 4.71 mL
50 mM 0.09 mL 0.47 mL 0.94 mL

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Reconstitution Calculator

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参考文献 for Brivaracetam

参考文献是支持产品生物活性的出版物。

Gillard et al (2011) Binding characteristics of brivaracetam, a selective, high affinity SV2A ligand in rat, mouse and human brain: relationship to anti-convulsant properties. Eur.J.Pharmacol. 664 36 PMID: 21575627

Rogawski (2016) A new SV2A ligand for epilepsy. Cell. 167 587 PMID: 27768878

If you know of a relevant reference for Brivaracetam, please let us know.

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关键词: Brivaracetam, Brivaracetam supplier, synaptic, vesicle, glycoprotein, 2A, SV2A, ligands, antiepileptic, Exocytosis, 7271, Tocris Bioscience

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