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Submit ReviewBRL 44408 maleate
说明： Selective α2A antagonist
化学名： 2-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-1H-isoindole maleate
纯度： ≥98% (HPLC)
生物活性 for BRL 44408 maleate
BRL 44408 maleate is a selective α2A-adrenoceptor antagonist (Ki = 1.7 nM and 144.5 nM at α2A and α2B-adrenergic receptors respectively). Increases hippocampal noradrenalin release following systemic administration.
许可信息
Sold with the permission of GlaxoSmithKline
技术数据 for BRL 44408 maleate
| 分子量 | 331.37 |
| 公式 | C13H17N3.C4H4O4 |
| 储存 | Desiccate at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 681806-46-2 |
| PubChem ID | 10382026 |
| InChI Key | DDIQGSUEJOOQQQ-BTJKTKAUSA-N |
| Smiles | OC(=O)\C=C/C(O)=O.CC1N(CC2=NCCN2)CC2=C1C=CC=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for BRL 44408 maleate
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 33.14 | 100 |
制备储备液 for BRL 44408 maleate
以下数据基于产品分子量 331.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.02 mL | 15.09 mL | 30.18 mL |
| 5 mM | 0.6 mL | 3.02 mL | 6.04 mL |
| 10 mM | 0.3 mL | 1.51 mL | 3.02 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.6 mL |
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产品说明书 for BRL 44408 maleate
参考文献 for BRL 44408 maleate
参考文献是支持产品生物活性的出版物。
Callado et al (1999) α2A-But not α2B/C-adrenoceptors modulate noradrenaline release in rat locus coeruleus: voltammetric data. Eur.J.Pharmacol. 366 35 PMID: 10064149
Gavin et al (1997) α2C-adrenoceptors mediate contractile responses to noradrenaline in the human saphenous vein. Naunyn Schmiedebergs Arch.Pharmacol. 355 406 PMID: 9089673
Kiss et al (1995) Subtype-specificity of the presynaptic α2-adrenoceptors modulating hippocampal NE release in rat. Brain Res. 674 238 PMID: 7796102
Young et al (1989) Novel α2-adrenoceptor antagonists show selectivity for α2A- and α2B-adrenoceptor subtypes. Eur.J.Pharmacol. 168 381 PMID: 2573535
If you know of a relevant reference for BRL 44408 maleate, please let us know.
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关键词: BRL 44408 maleate, BRL 44408 maleate supplier, Selective, alpha2A-adrenoceptor, a2a-adrenoceptor, a2a-Adrenergic, a2a-adrenergic, antagonists, Receptors, BRL44408, maleate, GlaxoSmithKline, GSK, Adrenergic, Alpha-2, 1133, Tocris Bioscience
2 篇 BRL 44408 maleate 的引用文献
引用文献是使用了 Tocris 产品的出版物。 BRL 44408 maleate 的部分引用包括：
Rennekamp et al (2016) σ1 receptor ligands control a switch between passive and active threat responses. Nat Chem Biol 12 552 PMID: 27239788
Backman et al (2013) Alpha-2 adrenergic stimulation triggers Achilles tenocyte hypercellularity: Comparison between two model systems. Scand J Med Sci Sports 23 687 PMID: 22292987
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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