BS 181 dihydrochloride

Cat. No. 5608 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective cdk7 inhibitor

化学名： N⁵-(6-Aminohexyl)-3-(1-methylethyl)-N⁷-(phenylmethyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine dihydrochloride

纯度： ≥99% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for BS 181 dihydrochloride

BS 181 dihydrochloride is a selective cdk7 inhibitor (IC₅₀ = 21 nM). Displays >40-fold selectivity for cdk7 over other cdks. Promotes cell cycle arrest and apoptosis in a range of cancer cells in vitro and inhibits MCF-7 tumor xenograft growth in mice.

技术数据 for BS 181 dihydrochloride

分子量	453.45
公式	C₂₂H₃₂N₆.2HCl
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	1883548-83-1
PubChem ID	91826108
InChI Key	XYXAMTBYYTXHSO-UHFFFAOYSA-N
Smiles	CC(C)C1=C2N=C(NCCCCCCN)C=C(NCC3=CC=CC=C3)N2N=C1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BS 181 dihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	45.34	100
	DMSO	45.34	100

制备储备液 for BS 181 dihydrochloride

以下数据基于产品分子量 453.45。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.21 mL	11.03 mL	22.05 mL
5 mM	0.44 mL	2.21 mL	4.41 mL
10 mM	0.22 mL	1.1 mL	2.21 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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产品说明书 for BS 181 dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for BS 181 dihydrochloride

参考文献是支持产品生物活性的出版物。

Ali et al (2009) The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity. Cancer Res. 69 6208 PMID: 19638587

If you know of a relevant reference for BS 181 dihydrochloride, please let us know.

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关键词: BS 181 dihydrochloride, BS 181 dihydrochloride supplier, cyclin-dependent, kinase, 7, cdk7, BS-181, inhibitors, cancer, apoptosis, activating, 1397219-81-6, inhibits, Cyclin-dependent, Kinase, Transcriptional, CDKs, 5608, Tocris Bioscience

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