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BTD

Cat. No. 6940 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective TRPC5 activator
化学名： 6-Methyl-N-[3-(tricyclo[3.3.1.13,7]dec-1-yloxy)propyl]-4H-1,2,4-benzothiadiazine-3-propanamide-1,1-dioxide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BTD

BTD is a selective TRPC5 activator (EC50 = 1.4 μM in a calcium influx assay, 1.3 μM in whole cell patch clamp assay). Displays >14.5-fold selectivity for TRPC5 over other TRP channels (EC50 = 20.6 μM for TRPM8). Also activates TRPC1:5 and TRPC4:5 heteromers.

技术数据 for BTD

分子量 459.61
公式 C24H33N3O4S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 896684-04-1
PubChem ID 46369355
InChI Key YXADKMPRWFBOHW-UHFFFAOYSA-N
Smiles CC1=CC=C2C(NC(CCC(=O)NCCCOC34CC5CC(CC(C5)C3)C4)=N[S]2(=O)=O)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BTD

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 45.96 100

制备储备液 for BTD

以下数据基于产品分子量 459.61。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.18 mL 10.88 mL 21.76 mL
5 mM 0.44 mL 2.18 mL 4.35 mL
10 mM 0.22 mL 1.09 mL 2.18 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Molarity Calculator

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产品说明书 for BTD

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for BTD

参考文献是支持产品生物活性的出版物。

Beckmann et al (2017) A benzothiadiazine derivative and methylprednisolone are novel and selective activators of transient receptor potential canonical 5 (TRPC5) channels. Cell Calcium. 66 10 PMID: 28807145

If you know of a relevant reference for BTD, please let us know.

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关键词: BTD, BTD supplier, selective, TRPC5, activators, transient, receptor, potental, channel, 5, activates, TRPC, 6940, Tocris Bioscience

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