BTS 54-505 hydrochloride

Name: BTS 54-505 hydrochloride
Brand: Tocris Bioscience
SKU: 2322

Cat. No. 2322 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2322 has been discontinued.

View all 5-HT Transporters products.

说明： Potent 5-HT and NA reuptake inhibitor (SNRI); active metabolite of sibutramine (Cat. No. 2290)

化学名： 1-(4-Chlorophenyl)-α-(2-methylpropyl)cyclobutanemethanamine hydrochloride

纯度： ≥99% (HPLC)

说明书

引用文献

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for BTS 54-505 hydrochloride

BTS 54-505 hydrochloride is a potently active primary amine metabolite of sibutramine (Cat. No. 2290), exhibits a similar pharmacological profile to the parent compound. Inhibits serotonin and noradrenalin reuptake more potently than sibutramine in vitro. Reduces food intake in rodents following i.c.v. administration and increases energy expenditure via thermogenesis in vivo.

技术数据 for BTS 54-505 hydrochloride

分子量	288.26
公式	C₁₅H₂₂NCl.HCl
储存	Desiccate at RT
纯度	≥99% (HPLC)
CAS Number	84484-78-6
PubChem ID	134771
InChI Key	KHRVYINTXCWNRF-UHFFFAOYSA-N
Smiles	Cl.CC(C)CC(N)C1(CCC1)C1=CC=C(Cl)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for BTS 54-505 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for BTS 54-505 hydrochloride

参考文献是支持产品生物活性的出版物。

Luscombe et al (1989) The contribution of metabolites to the rapid and potent down-regulation of rat cortical beta-adrenoceptors by the putative antidepressant sibutr. hydrochloride. Neuropharmacology 28 129 PMID: 2541365

Gundlah et al (1997) In vivo criteria to differentiate monoamine reuptake inhibitors from releasing agents: sibutr. is a reuptake inhibitor. J.Pharmacol.Exp.Ther. 283 581 PMID: 9353373

Liu et al (2002) Mechanism of the thermogenic effect of Metabolite 2 (BTS 54 505), a major pharmacologically active metabolite of the novel anti-obesity drug, sibutr. Int.J.Obes.Relat.Metab.Disord. 26 1245 PMID: 12187403

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