BU 224 hydrochloride

Cat. No. 0725 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent, selective I₂ ligand. Putative antagonist

化学名： 2-(4,5-Dihydroimidazol-2-yl)quinoline hydrochloride

引用文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for BU 224 hydrochloride

BU 224 hydrochloride is a high affinity ligand for the imidazoline I₂ binding site (K_i = 2.1 nM). Putative I₂ antagonist; antagonizes the effects of imidazoline ligands on morphine antinociception. Produces ipsiversive rotational behavior in rats with a full 6-OHDA lesion of the nigrostriatal tract.

技术数据 for BU 224 hydrochloride

分子量	233.7
公式	C₁₂H₁₁N₃.HCl
储存	Desiccate at RT
CAS Number	205437-64-5
PubChem ID	11957470
InChI Key	DDFHQXAQWZWRSQ-UHFFFAOYSA-N
Smiles	Cl.C1CN=C(N1)C1=NC2=CC=CC=C2C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BU 224 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	2.34	10

制备储备液 for BU 224 hydrochloride

以下数据基于产品分子量 233.7。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.1 mM	42.79 mL	213.95 mL	427.9 mL
0.5 mM	8.56 mL	42.79 mL	85.58 mL
1 mM	4.28 mL	21.39 mL	42.79 mL
5 mM	0.86 mL	4.28 mL	8.56 mL

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产品说明书 for BU 224 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for BU 224 hydrochloride

参考文献是支持产品生物活性的出版物。

Hudson et al (1999) Novel selective compounds for the investigation of imidazoline receptors. Ann.N.Y.Acad.Sci. 881 81 PMID: 10415900

MacInnes and Dut (2004) Locomotor effects of imidazoline I₂-site-specific ligands and monoamine oxidase inhibitors in rats with a unilateral 6-hydroxyDA lesion of the nigrostriatal pathway. Br.J.Pharmacol. 143 952 PMID: 15545290

Sanchez-Blasquez et al (2000) Activation of I₂-imidazoline receptors enhances supraspinal mor. analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br.J.Pharmacol. 130 146 PMID: 10781010

Hudson et al (1994) Affinity and selectivity of BU224 and BU239 for rabbit brain non-adrenoceptor idazoxan binding sites (I₂) sites). Br.J.Pharmacol. 112 320P

If you know of a relevant reference for BU 224 hydrochloride, please let us know.

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关键词: BU 224 hydrochloride, BU 224 hydrochloride supplier, Potent, selective, I2, ligand, Putative, antagonists, Imidazoline, Receptors, BU224, hydrochloride, 0725, Tocris Bioscience

2 篇 BU 224 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BU 224 hydrochloride 的部分引用包括：

Sánchez-Blázquez et al (2000) Activation of I(2)-imidazoline receptors enhances supraspinal mor. analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br J Pharmacol 130 146 PMID: 10781010

Gründemann et al (2002) Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells. Br J Pharmacol 137 910 PMID: 12411423

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