BU 224 hydrochloride

Name: BU 224 hydrochloride
Brand: Tocris Bioscience
SKU: 0725

Cat. No. 0725 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

0725 has been discontinued.

View all I<sub>2</sub> Receptors products.

说明： Potent, selective I₂ ligand. Putative antagonist

化学名： 2-(4,5-Dihydroimidazol-2-yl)quinoline hydrochloride

说明书

引用文献 (2)

生物活性技术数据说明书参考文献

生物活性 for BU 224 hydrochloride

BU 224 hydrochloride is a high affinity ligand for the imidazoline I₂ binding site (K_i = 2.1 nM). Putative I₂ antagonist; antagonizes the effects of imidazoline ligands on morphine antinociception. Produces ipsiversive rotational behavior in rats with a full 6-OHDA lesion of the nigrostriatal tract.

技术数据 for BU 224 hydrochloride

分子量	233.7
公式	C₁₂H₁₁N₃.HCl
储存	Desiccate at RT
CAS Number	205437-64-5
PubChem ID	11957470
InChI Key	DDFHQXAQWZWRSQ-UHFFFAOYSA-N
Smiles	Cl.C1CN=C(N1)C1=NC2=CC=CC=C2C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for BU 224 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for BU 224 hydrochloride

参考文献是支持产品生物活性的出版物。

Hudson et al (1999) Novel selective compounds for the investigation of imidazoline receptors. Ann.N.Y.Acad.Sci. 881 81 PMID: 10415900

MacInnes and Dut (2004) Locomotor effects of imidazoline I₂-site-specific ligands and monoamine oxidase inhibitors in rats with a unilateral 6-hydroxyDA lesion of the nigrostriatal pathway. Br.J.Pharmacol. 143 952 PMID: 15545290

Sanchez-Blasquez et al (2000) Activation of I₂-imidazoline receptors enhances supraspinal mor. analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br.J.Pharmacol. 130 146 PMID: 10781010

Hudson et al (1994) Affinity and selectivity of BU224 and BU239 for rabbit brain non-adrenoceptor idazoxan binding sites (I₂) sites). Br.J.Pharmacol. 112 320P

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关键词: BU 224 hydrochloride, BU 224 hydrochloride supplier, Potent, selective, I2, ligand, Putative, antagonists, Imidazoline, Receptors, BU224, hydrochloride, 0725, Tocris Bioscience

2 篇 BU 224 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BU 224 hydrochloride 的部分引用包括：

Gründemann et al (2002) Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells. Br J Pharmacol 137 910 PMID: 12411423

Sánchez-Blázquez et al (2000) Activation of I(2)-imidazoline receptors enhances supraspinal mor. analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br J Pharmacol 130 146 PMID: 10781010