Buspirone hydrochloride

Discontinued Product

0962 has been discontinued.

View all 5-HT<sub>1A</sub> Receptors products.
说明: 5-HT1A partial agonist
化学名: 8-[4-[4-(2-Pyrimidinyl)-1-pipirazinyl]butyl]-8-azaspiro[4,5]decane-7,9-dione hydrochloride
纯度: ≥99% (HPLC)
说明书
引用文献 (4)
评论
文献 (3)

生物活性 for Buspirone hydrochloride

Buspirone hydrochloride is a classic 5-HT1A partial agonist with relatively high affinity (Ki = 9.3 - 29.5 nM). A clinically effective anxiolytic.

技术数据 for Buspirone hydrochloride

分子量 421.97
公式 C21H31N5O2.HCl
储存 Desiccate at +4°C
纯度 ≥99% (HPLC)
CAS Number 33386-08-2
PubChem ID 36431
InChI Key RICLFGYGYQXUFH-UHFFFAOYSA-N
Smiles Cl.O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)C1=NC=CC=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Buspirone hydrochloride

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关键词: Buspirone hydrochloride, Buspirone hydrochloride supplier, 5-HT1A, partial, agonists, Serotonin, Receptors, 0962, Tocris Bioscience

4 篇 Buspirone hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Buspirone hydrochloride 的部分引用包括:

Gadgaard & Jensen (2020) Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay. Biochem Pharmacol 175 PMID: 32088264

Gutierrez et al (2019) Endothelin neurotransmitter signalling controls zebrafish social behaviour. Sci Rep 9 3040 PMID: 30816294

Norton and Gutiérrez (2019) The three-spined stickleback as a model for behavioural neuroscience. PLoS One 14 e0213320 PMID: 30913214

Garavaglia et al (2010) Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates. BMC Neurosci 11 7 PMID: 20085655


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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意,Tocris 仅会向正规科研企业/机构地址发送文献。


5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.