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Submit ReviewBuspirone hydrochloride is a classic 5-HT1A partial agonist with relatively high affinity (Ki = 9.3 - 29.5 nM). A clinically effective anxiolytic.
分子量 | 421.97 |
公式 | C21H31N5O2.HCl |
储存 | Desiccate at +4°C |
纯度 | ≥99% (HPLC) |
CAS Number | 33386-08-2 |
PubChem ID | 36431 |
InChI Key | RICLFGYGYQXUFH-UHFFFAOYSA-N |
Smiles | Cl.O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)C1=NC=CC=N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
参考文献是支持产品生物活性的出版物。
Cao and Rodgers (1997) Comparative behavioural profiles of busp. and its metabolite 1-(2-pyrimidinyl)-piperazine (1-PP) in the murine elevated plus-maze. Neuropharmacology 36 1089 PMID: 9294974
Goa and Ward (1986) Buspirone - a preliminary review on its pharmacological properties and therapeutic efficacy as an anxiolytic. Drugs 32 114 PMID: 2874976
Gobert et al (1999) Buspirone modulates basal and fluoxetine-stimulated dialysate levels of DA, noradrenaline and serotonin in the frontal cortex of freely moving rats: activation of serotonin1A receptors and blockade of α2-adrenoceptors underlie i Neuroscience 93 1251 PMID: 10501449
Merck Index 12 1528
关键词: Buspirone hydrochloride, Buspirone hydrochloride supplier, 5-HT1A, partial, agonists, Serotonin, Receptors, 0962, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 Buspirone hydrochloride 的部分引用包括:
Gadgaard & Jensen (2020) Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay. Biochem Pharmacol 175 PMID: 32088264
Gutierrez et al (2019) Endothelin neurotransmitter signalling controls zebrafish social behaviour. Sci Rep 9 3040 PMID: 30816294
Norton and Gutiérrez (2019) The three-spined stickleback as a model for behavioural neuroscience. PLoS One 14 e0213320 PMID: 30913214
Garavaglia et al (2010) Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates. BMC Neurosci 11 7 PMID: 20085655
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意,Tocris 仅会向正规科研企业/机构地址发送文献。
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
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