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Submit ReviewBW-B 70C is a potent and selective inhibitor of 5-lipoxygenase. Long half-life and high oral bioavailability in vivo.
分子量 | 316.33 |
公式 | C17H17FN2O3 |
储存 | Desiccate at -20°C |
纯度 | ≥98% (HPLC) |
CAS Number | 134470-38-5 |
PubChem ID | 5353454 |
InChI Key | UAIYNMRLUHHRMF-AATRIKPKSA-N |
Smiles | CC(\C=C\C1=CC(OC2=CC=C(F)C=C2)=CC=C1)N(O)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
参考文献是支持产品生物活性的出版物。
Payne et al (1991) Hydroxamic acids and hydroxyureas as novel, selective 5-lipoxygenase inhibitors for possible use in asthma. Agents Actions Suppl. 34 189 PMID: 1793063
Salmon et al (1990) Inhibition of 5-lipoxygenase: development of hydroxamic acids and hydroxyureas as potential therapeutic agents. Adv.Prost.Throm.Leuk.Res. 21 109 PMID: 1847758
Yeadon et al (1993) Effect of BW B70C, a novel inhibitor of arachidonic acid 5-lipoxygenase, on allergen-induced bronchoconstriction and late-phase lung eosinophil accumulation in sensitised guinea-pigs. Agents Actions 38 8 PMID: 8480540
关键词: BW-B 70C, BW-B 70C supplier, 5-lipoxygenase, inhibitors, oxygenases, inhibits, oxidases, BWB70C, 5-LOX, Lipoxygenase, 1304, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 BW-B 70C 的部分引用包括:
Ruparel et al (2012) Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation. J Cell Biol 153 2031 PMID: 22633978
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