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BX 430

Cat. No. 5545 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective P2X4 allosteric antagonist
化学名： N-[2,6-Dibromo-4-(1-methylethyl)phenyl]-N'-(3-pyridinyl)urea
纯度： ≥99% (HPLC)
说明书
引用文献 (2)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for BX 430

BX 430 is a selective P2X4 allosteric antagonist (IC50 = 0.54 μM). Exhibits >10-fold selectivity for human P2X4 receptors over P2X1, P2X2, P2X3, P2X5 and P2X7 receptors. Binds noncompetitively at extracellular allosteric site. Effective at human and zebrafish, but not mouse and rat P2X4 receptors.

技术数据 for BX 430

分子量 413.11
公式 C15H15Br2N3O
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 688309-70-8
PubChem ID 2810999
InChI Key JFNKIJKRXKPQCC-UHFFFAOYSA-N
Smiles CC(C)C1=CC(Br)=C(NC(NC2=CN=CC=C2)=O)C(Br)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for BX 430

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 41.31 100
ethanol 41.31 100

制备储备液 for BX 430

以下数据基于产品分子量 413.11。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.42 mL 12.1 mL 24.21 mL
5 mM 0.48 mL 2.42 mL 4.84 mL
10 mM 0.24 mL 1.21 mL 2.42 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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参考文献 for BX 430

参考文献是支持产品生物活性的出版物。

Ase et al (2015) Identification and characterization of a selective allosteric antagonist of human P2X4 receptor channels Mol.Pharmacol. 87 606 PMID: 25597706

If you know of a relevant reference for BX 430, please let us know.

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关键词: BX 430, BX 430 supplier, BX430, selective, allosteric, noncompetitive, antagonists, antaognism, purinergic, receptors, purinoceptors, P2X4, P2X, Receptors, 5545, Tocris Bioscience

2 篇 BX 430 的引用文献

引用文献是使用了 Tocris 产品的出版物。 BX 430 的部分引用包括：

Datta et al (2019) HIV-1 gp120 Promotes Lysosomal Exocytosis in Human Schwann Cells. Front Cell Neurosci 13 329 PMID: 31379513

Belinda L et al (2020) Pharmacological and genetic characterisation of the canine P2X4 receptor. Br J Pharmacol 177 2812-2829 PMID: 32017039

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

P2X and P2Y Receptors Scientific Review

P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.