BYK 191023 dihydrochloride

Name: BYK 191023 dihydrochloride
Brand: Tocris Bioscience
SKU: 2866

Cat. No. 2866 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2866 has been discontinued.

View all iNOS products.

说明： Potent and selective inhibitor of iNOS

化学名： 2-[2-(4-Methoxy-2-pyridinyl)ethyl]-1H-imidazo[4,5-b]pyridine dihydrochloride

纯度： ≥99% (HPLC)

说明书

引用文献

生物活性技术数据说明书参考文献

生物活性 for BYK 191023 dihydrochloride

BYK 191023 dihydrochloride is a potent and selective inhibitor of inducible nitric oxide synthase (iNOS) (IC₅₀ values are 86, 17000, 162000 nM for iNOS, nNOS and eNOS respectively). Acts in an NADPH- and time-dependent manner. Active in vivo, reverses pathological hypotension in the rodent endotoxin model.

许可信息

Sold with the permission of Nycomed

技术数据 for BYK 191023 dihydrochloride

分子量	327.21
公式	C₁₄H₁₄N₄O.2HCl
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	1216722-25-6
PubChem ID	56972216
InChI Key	ZVNITETZYOKESF-UHFFFAOYSA-N
Smiles	COC1=CC(CCC2=NC(N=CC=C3)=C3N2)=NC=C1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for BYK 191023 dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for BYK 191023 dihydrochloride

参考文献是支持产品生物活性的出版物。

Lehner et al (2006) In vivo characterisation of the novel imidazopyridine BYK191023 2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine, a potent and highly selective inhibitor of inducible nitric-oxide synthase. J.Pharmacol.Exp.Ther. 317 181 PMID: 16368897

Strub et al (2006) The novel imidazopyridine 2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine (BYK191023) is a highly selective inhibitor of the inducible nitric-oxide synthase. Mol.Pharmacol. 68 328

Tiso et al (2008) BYK191023 (2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine) is an NADPH- and time-dependent irreversible inhibitor of inducible nitric-oxide synthase. Mol.Pharmacol. 72 1244

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篇 BYK 191023 dihydrochloride 的引用文献

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