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Bz 423

Cat. No. 5791 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： ATP synthase inhibitor; proapoptotic
化学名： 7-Chloro-1,3-dihydro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthalenylmethyl)-2H-1,4-benzodiazepin-2-one
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Bz 423

Bz 423 is an ATP synthase inhibitor (IC50 ~5 μM). Binds the oligomycin sensitivity conferring protein (OSCP) component of mitochondrial F1F0-ATPase in vitro resulting in generation of superoxide and apoptosis. Kills primary B and T cell in mice in vivo. Suppresses autoimmunity and prolongs survival in mouse lupus model.

技术数据 for Bz 423

分子量 440.92
公式 C27H21ClN2O2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 216691-95-1
PubChem ID 5497206
InChI Key IJEUIRDNQUQMFU-UHFFFAOYSA-N
Smiles CN1C2=CC=C(C=C2C(C3=CC=C(C=C3)O)=NC(C1=O)CC4=CC5=CC=CC=C5C=C4)Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Bz 423

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 44.09 100
ethanol 44.09 100

制备储备液 for Bz 423

以下数据基于产品分子量 440.92。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.27 mL 11.34 mL 22.68 mL
5 mM 0.45 mL 2.27 mL 4.54 mL
10 mM 0.23 mL 1.13 mL 2.27 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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参考文献 for Bz 423

参考文献是支持产品生物活性的出版物。

Johnson et al (2005) Identification and validation of the mitochondrial F1F0-ATPase as the molecular target of the immunomodulatory benzodiazepine Bz-423. Chem.Biol. 12 485 PMID: 15850986

Blatt et al (2009) Bz-423 superoxide signals B cell apoptosis via Mcl-1, Bak, and Bax. Biochem.Pharmacol. 15 966 PMID: 19481066

Blatt et al (2002) Benzodiazepine-induced superoxide signals B cell apoptosis: mechanistic insight and potential therapeutic utility. J.Clin.Invest. 110 1123 PMID: 12393848

If you know of a relevant reference for Bz 423, please let us know.

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关键词: Bz 423, Bz 423 supplier, Bz423, ATP, synthase, inhibitors, inhibits, pro-apoptotic, oligomycin, sensitivity, conferring, protein, OSCP, autoimmunity, superoxide, generation, Other, Synthases/Synthetases, Apoptosis, Inducers, 5791, Tocris Bioscience

1 篇 Bz 423 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Bz 423 的部分引用包括：

Giorgia et al (2020) Impaired flickering of the permeability transition pore causes SPG7 spastic paraplegia. EBioMedicine 61 103050 PMID: 33045469

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