c-Di-AMP sodium salt

Name: c-Di-AMP sodium salt
Brand: Tocris Bioscience
SKU: 5901
Rating: 4 (1 reviews)

Cat. No. 5901 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Endogenous STING and DDX41 agonist; activates STING-dependent signaling

化学名： 3',5'-Cyclic diadenylic acid sodium salt

纯度： ≥98% (HPLC)

说明书

引用文献

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for c-Di-AMP sodium salt

c-Di-AMP sodium salt is an endogenous STING and DDX41 agonist; mediates DDX41-STING interaction. Activates STING-dependent IFN-β production in mouse and human cells. Also A_2A inverse agonist. Selectively induces apoptosis of monocytes in human PBMC cultures and in NSG mice transplanted with human CD34⁺ cells.

This product is sold in units of 702μg, equivalent to 1μmol.

技术数据 for c-Di-AMP sodium salt

分子量	702.38
公式	C₂₀H₂₂N₁₀Na₂O₁₂P₂
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	2734909-87-4
PubChem ID	11158091
InChI Key	PDXMFTWFFKBFIN-XPWFQUROSA-N
Smiles	O=P(O[C@H]1[C@H]([C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1CO4)O)(O[Na])OC[C@@H]5[C@H]([C@H]([C@H](N6C=NC7=C6N=CN=C7N)O5)O)OP4(O[Na])=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for c-Di-AMP sodium salt

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	14.05	20

制备储备液 for c-Di-AMP sodium salt

以下数据基于产品分子量 702.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.2 mM	7.12 mL	35.59 mL	71.19 mL
1 mM	1.42 mL	7.12 mL	14.24 mL
2 mM	0.71 mL	3.56 mL	7.12 mL
10 mM	0.14 mL	0.71 mL	1.42 mL

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产品说明书 for c-Di-AMP sodium salt

分析证书/产品说明书

化学品安全技术说明书

参考文献 for c-Di-AMP sodium salt

参考文献是支持产品生物活性的出版物。

Parvatiyar et al (2012) The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I IF. immune response. Nat.Immunol. 13 1155 PMID: 23142775

Tosolini et al (2015) Human monocyte recognition of adenosine-based cyclic dinucleotides unveils the A_2a G_αs protein-coupled receptor tonic inhibition of mitochondrially induced cell death. Mol.Cell.Biol. 35 479 PMID: 25384972

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关键词: c-Di-AMP sodium salt, c-Di-AMP sodium salt supplier, STING, DDX41, ligands, activates, activators, adenosine, A2A, receptors, inverse, agonists, agonism, apoptosis, Adenosine, Receptors, STING-Dependent, Signaling, 5901, Tocris Bioscience

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Induction of type I IFNs with c-di-AMP in different cell lines.

By Anonymous on 08/19/2019

种属： Human

Induction of type I IFNs with c-di-AMP was studied in a variety ofcell lines. The human monocytic cell line THP-1 has been shown to expressall the CDSs4-6 with the exception of DAI.

Make sure to resuspend c-di-AMP and stimulate cells with 1-100 mg/ml c-di-AMP for 16-48 hours. Monitor induction of type I IFNs by measuring the levels of IRF-induced Lucia luciferase in the cell culture supernatant