c-Di-GMP sodium salt

Cat. No. 5900 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Endogenous STING and DDX41 agonist; activates STING-dependent signaling

化学名： 3',5'-Cyclic diguanylic acid sodium salt

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for c-Di-GMP sodium salt

c-Di-GMP sodium salt is an endogenous STING and DDX41 agonist; mediates DDX41-STING interaction. Activates STING-dependent IFN-β production in mouse and human cells. Also induces an antitumor response in a lung B16-10 melanoma mouse model, when administered intravenously within YSKO5-liposomes.

This product is sold in units of 730μg, equivalent to 1μmol.

技术数据 for c-Di-GMP sodium salt

分子量	734.37
公式	C₂₀H₂₂N₁₀Na₂O₁₄P₂
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	2222132-40-1
PubChem ID	101199074
InChI Key	SVIXOIGPVFFABR-XDODWTFASA-L
Smiles	O=P(O[C@H]1[C@H]([C@H](N6C=NC7=C6N=C(NC7=O)N)O[C@@H]1CO2)O)(O[Na])OC[C@@H]3[C@H]([C@H]([C@H](N4C=NC5=C4N=C(NC5=O)N)O3)O)OP2(O[Na])=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for c-Di-GMP sodium salt

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	14.69	20

制备储备液 for c-Di-GMP sodium salt

以下数据基于产品分子量 734.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.2 mM	6.81 mL	34.04 mL	68.09 mL
1 mM	1.36 mL	6.81 mL	13.62 mL
2 mM	0.68 mL	3.4 mL	6.81 mL
10 mM	0.14 mL	0.68 mL	1.36 mL

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产品说明书 for c-Di-GMP sodium salt

分析证书/产品说明书

化学品安全技术说明书

参考文献 for c-Di-GMP sodium salt

参考文献是支持产品生物活性的出版物。

Parvatiyar et al (2012) The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I IF. immune response. Nat.Immunol. 13 1155 PMID: 23142775

Burdette et al (2011) STING is a direct innate immune sensor of cyclic di-GMP. Nature 478 515 PMID: 21947006

Nakamura et al (2015) Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma. J.Control Release 216 149 PMID: 26282097

If you know of a relevant reference for c-Di-GMP sodium salt, please let us know.

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关键词: c-Di-GMP sodium salt, c-Di-GMP sodium salt supplier, STING, DDX41, ligands, activates, activators, cancer, immunotherapy, 61093-23-0, STING-Dependent, Signaling, 5900, Tocris Bioscience

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