c-JUN peptide

Cat. No. 1989 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Peptide inhibitor of JNK/c-Jun interaction

纯度： ≥95% (HPLC)

引用文献 (2)

文献 (1)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for c-JUN peptide

c-JUN peptide is a peptide comprising residues 33 - 57 of the JNK binding (δ) domain of human c-Jun. Disrupts JNK/c-Jun interaction leading to inhibition of serum-induced c-Jun phosphorylation, up-regulation of p21^cip/waf and modulation of inflammatory gene expression. Specifically induces apoptosis in HeLa tumor cells.

技术数据 for c-JUN peptide

分子量	2743.55
公式	C₁₂₁H₂₁₀N₃₆O₃₄S
序列	ILKQSMTLNLADPVGSLKPHLRAKN
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	610273-01-3
PubChem ID	90488732
InChI Key	OVPPMIXGVMXSNS-CLIBVNCNSA-N
Smiles	[H]N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for c-JUN peptide

溶解性	Soluble to 1 mg/ml in water

产品说明书 for c-JUN peptide

分析证书/产品说明书

化学品安全技术说明书

参考文献 for c-JUN peptide

参考文献是支持产品生物活性的出版物。

Holzberg et al (2003) Disruption of the c-JUN-JNK complex by a cell-permeable peptide containing the c-JUN d domain induces apoptosis and affects a distinct set of interleukin-1 induced inflammatory genes. J.Biol.Chem. 278 40213 PMID: 12832416

If you know of a relevant reference for c-JUN peptide, please let us know.

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查看全部 JNK/c-Jun Inhibitors

关键词: c-JUN peptide, c-JUN peptide supplier, JNK, c-Jun, interaction, inhibitors, inhibits, Peptide, N-Terminal, Kinases, Transcription, Factors, Mitogen-Activated, protein, JNK/c-jun, AP-1, 1989, Tocris Bioscience

2 篇 c-JUN peptide 的引用文献

引用文献是使用了 Tocris 产品的出版物。 c-JUN peptide 的部分引用包括：

Moreau et al (2015) Transcriptional regulation of Annexin A2 promotes starvation-induced autophagy. J Urol 6 8045 PMID: 26289944

Daniels et al (2017) Inhibiting IL-1 signaling pathways to inhibit catabolic processes in disc degeneration. J Orthop Res 35 74 PMID: 27391542

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for c-JUN peptide

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.