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Submit ReviewCaerulein
说明： CCK agonist
纯度： ≥95% (HPLC)
生物活性 for Caerulein
Caerulein is a CCK agonist. Stimulates biosynthesis of pancreatic enzymes in AR4-2J pancreatic cells in vitro. Induces acute pancreatitis in mice. Also enhances proteasome activity in Gdeg mice.
技术数据 for Caerulein
| 分子量 | 1352.4 |
| 公式 | C58H73N13O21S2 |
| 序列 |
XQDYTGWMDF (Modifications: X = Glp, Tyr-4 = Tyr(SO3H), Phe-10 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 17650-98-5 |
| PubChem ID | 16132921 |
| InChI Key | YRALAIOMGQZKOW-UHFFFAOYSA-N |
| Smiles | CC(C(C(=O)NCC(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CCSC)C(=O)NC(CC(=O)O)C(=O)NC(CC3=CC=CC=C3)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)OS(=O)(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)N)NC(=O)C5CCC(=O)N5)O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Caerulein
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for Caerulein
参考文献 for Caerulein
参考文献是支持产品生物活性的出版物。
Murakami et al (2017) Yes-associated protein mediates immune reprogramming in pancreatic ductal adenocarcinoma. Oncogene 36 1232 PMID: 27546622
Furuyama et al (2016) Proteasome activity is required for the initiation of precancerous pancreatic lesions. Sci.Rep. 6 27044 PMID: 27244456
Pradel et al (1993) Caerulein and gastrin(2-17 ds) regulate differently synthesis of secretory enzymes, mRNA levels and cell proliferation in pancreatic acinar cells (AR4-2J). Biochem.J. 290 219 PMID: 7679894
If you know of a relevant reference for Caerulein, please let us know.
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关键词: Caerulein, Caerulein supplier, Cholecystokinin, Receptors, CCK1, CCK2, agonists, pancreatitis, Non-selective, CCK, 6264, Tocris Bioscience
3 篇 Caerulein 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Caerulein 的部分引用包括：
Li et al (2021) Parabacteroides produces acetate to alleviate heparanase-exacerbated acute pancreatitis through reducing neutrophil infiltration. Microbiome 9 115 PMID: 34016163
Xiaofeng et al (2022) A microRNA checkpoint for Ca2+ signaling and overload in acute pancreatitis. Mol Ther 30 1754-1774 PMID: 35077860
Stephen J et al (2020) TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation. J Clin Invest 130 2527-2541 PMID: 31999644
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Caerulein 的评论
平均评分: 5 (Based on 1 Review.)
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Excellent product.
By
Akbar Ahmad on 01/04/2018
分析类型： In Vivo
种属： Mouse
Dissolve in recommended solvent and 50microgram/ kg, intraperitoneally administered to mice for 5 times to induce acute pancreatitis.
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