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Calcipotriol

Cat. No. 2700 3 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Vitamin D3 analog
别名： MC 903
化学名： (1α,3β,5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1,3,24-triol
纯度： ≥98% (HPLC)
说明书
引用文献 (3)
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Calcipotriol

Calcipotriol is a vitamin D3 analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; exhibits antiproliferative activity against human HL-60, HL60/MX2, keratinocytes, MCF-7, T47D, SCC-25, and mouse WEHI-3 cancer cell lines. Calcipotriol suppresses skin cancer development in mice in a thymic stromal lymphopoietin (TSLP)-dependent manner. Calcipotriol promotes the differentiation of keratinocytes. In human T cells and in psoriatic skin, Calcipotriol increases IL-10 secretion, induces secretion of type 2 cytokines by T cells and modulates the differentiation of dendritic cells and T cells.

技术数据 for Calcipotriol

分子量 412.6
公式 C27H40O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 112965-21-6
PubChem ID 5288783
InChI Key LWQQLNNNIPYSNX-UROSTWAQSA-N
Smiles [H][C@@]12[C@]([C@]([C@@H](/C=C/[C@@H](O)C4CC4)C)([H])CC2)(C)CCC/C1=C\C=C3/C([C@@H](O)C[C@H](O)C3)=C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Calcipotriol

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 41.26 100
ethanol 41.26 100

制备储备液 for Calcipotriol

以下数据基于产品分子量 412.6。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.42 mL 12.12 mL 24.24 mL
5 mM 0.48 mL 2.42 mL 4.85 mL
10 mM 0.24 mL 1.21 mL 2.42 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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产品说明书 for Calcipotriol

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Calcipotriol

参考文献是支持产品生物活性的出版物。

Binderu (1993) Comparison of calcipotriol with selected metabolites and analogues of vitamin D3: effects on cell growth regulation in vitro and calcium metabolism in vivo. Pharmacol.Toxicol. 72 240 PMID: 8396769

Knutson et al (1997) Pharmacokinetics and systemic effect on calcium homeostasis of 1α,24-dihydroxyvitamin D2 in rats. Biochem.Pharmacol. 53 829 PMID: 9113104

Wietrzyk et al (2007) Antitumor properties of diastereomeric and geometric analogs of vitamin D3. Anticancer Drugs 18 447 PMID: 17351397

Lovato et al (2016) Calcipotriol and betamethasone dipropionate exert additive inhibitory effects on the cytokine expression of inflammatory dendritic cell-Th17 cell axis in psoriasis. J.Dermatol.Sci. 81 153 PMID: 26794805

Cunningham et al (2017) Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy. J.Clin.Invest. 127 106 PMID: 27869649

If you know of a relevant reference for Calcipotriol, please let us know.

按标靶查看相关产品

关键词: Calcipotriol, Calcipotriol supplier, Vitamin, D3, D, Receptors, VDR-like, MC903, analogues, MC, 903, 2700, Tocris Bioscience

3 篇 Calcipotriol 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Calcipotriol 的部分引用包括：

Malhotra et al (2018) RORα-expressing T regulatory cells restrain allergic skin inflammation. Sci Immunol 3 PMID: 29500225

Wei et al (2018) Vitamin D switches BAF complexes to protect β cells. Cell 173 1135 PMID: 29754817

Landheer et al (2015) TSLP is differentially regulated by vitamin D3 and cytokines in human skin. Dev.Biol. 3 32 PMID: 25866638

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Calcipotriol 的评论

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MC903 treatment and pathology assessment.
By Jing Feng on 01/10/2018
分析类型： In Vivo
种属： Mouse

MC903 was used to induce an Atopical Dermatitis-like inflammation and itch

review image