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Calcitriol

Cat. No. 2551 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Vitamin D receptor (VDR) agonist
别名： 1,25-Dihydroxyvitamin D3
化学名： (1α,3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol
纯度： ≥99% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Calcitriol

Calcitriol is an active metabolite of vitamin D3 that activates the vitamin D receptor (VDR). Displays calcemic actions; stimulates intestinal and renal Ca2+ absorption and regulates bone Ca2+ turnover. Exhibits antitumor activity; inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.

技术数据 for Calcitriol

分子量 416.64
公式 C27H44O3
储存 Store at -20°C
纯度 ≥99% (HPLC)
CAS Number 32222-06-3
PubChem ID 5280453
InChI Key GMRQFYUYWCNGIN-NKMMMXOESA-N
Smiles C[C@@](CCC2)3[C@](CC[C@@]([H])3[C@@H](CCCC(C)(C)O)C)([H])/C2=C/C=C(C[C@@H](O)C[C@@H]1O)\C1=C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Calcitriol

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 8.33 20
ethanol 2.08 5

制备储备液 for Calcitriol

以下数据基于产品分子量 416.64。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 12 mL 60 mL 120.01 mL
1 mM 2.4 mL 12 mL 24 mL
2 mM 1.2 mL 6 mL 12 mL
10 mM 0.24 mL 1.2 mL 2.4 mL

Molarity Calculator

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产品说明书 for Calcitriol

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Calcitriol

参考文献是支持产品生物活性的出版物。

Canalejo et al (2000) The in vitro effect of calci. on parathyroid cell proliferation and apoptosis. J.Am.Soc.Nephrol. 11 1865 PMID: 11004217

Beer and Myrthue (2004) Calcitriol in cancer treatment: from the lab to the clinic. Mol.Cancer Ther. 3 373 PMID: 15026558

Nijenhuis et al (2006) The novel vitamin D analog ZK191784 as an intestine-specific vitamin D antagonist. FASEB J. 20 1589 PMID: 16873882

If you know of a relevant reference for Calcitriol, please let us know.

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关键词: Calcitriol, Calcitriol supplier, Vitamin, D, receptor, VDR, agonists, Receptors, VDR-like, 1,25-DihydroxyvitaminD3, 1,25-Dihydroxyvitamin, D3, 2551, Tocris Bioscience

2 篇 Calcitriol 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Calcitriol 的部分引用包括：

Pal et al (2010) Osteocalcin positive mononuclear cells are associated with the severity of aortic calcification. J Neurosci 210 88 PMID: 20004897

Sharma et al (2015) A novel cytostatic form of autophagy in sensitization of non-small cell lung cancer cells to radiation by vitamin D and the vitamin D analog, EB 1089. Atherosclerosis 10 2346 PMID: 25629933

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