Calyculin A

Name: Calyculin A
Brand: Tocris Bioscience
SKU: 1336
Rating: 5 (1 reviews)

Cat. No. 1336 9 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Protein phosphatase 1 and 2A inhibitor

化学名： N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyl-7,9,11,13-tetradecatetraenyl]-9-hydroxy-4,4,8-trimethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propenyl]-2-oxazoly]butyl]-4-deoxy-4-(dimethylamino)-5-O-methyl-L-ribonamide

纯度： ≥97% (HPLC)

说明书

引用文献 (9)

生物活性技术数据说明书参考文献

生物活性 for Calyculin A

Calyculin A is a potent and selective cell-permeable inhibitor of protein phosphatase 1 (IC₅₀ = 0.3 - 0.7 nM) and protein phosphatase 2A (IC₅₀ = 0.5 - 1 nM). Displays > 10,000,000-fold selectivity over PP2B and PP2C.

Note: This product is typically prepared in DMSO.

技术数据 for Calyculin A

分子量	1009.18
公式	C₅₀H₈₁N₄O₁₅P
储存	Store at -20°C
纯度	≥97% (HPLC)
CAS Number	101932-71-2
PubChem ID	3894
InChI Key	ULTTYPMRMMDONC-UHFFFAOYSA-N
Smiles	O[C@H]1[C@H](C)[C@H](C/C=C/C3=COC([C@@H](C)CCNC([C@H]([C@H]([C@@H](N(C)C)COC)O)O)=O)=N3)O[C@]2([C@](C)(C)[C@@H](OP(O)(O)=O)[C@]([C@@H](OC)C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C(C)/C(C)=C/C=C/C(C)=C\C#N)([H])O2)C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Calyculin A

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Calyculin A

参考文献是支持产品生物活性的出版物。

Favre et al (1997) Differential inhibition and posttranslational modification of protein phosphatase 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid, and tautomycin. J.Biol.Chem. 272 13856 PMID: 9153244

Ishihara et al (1989) Calyculin A and okadaic acid: inhibitors of protein phosphatase activity. Biochem.Biophys.Res.Commun. 159 871 PMID: 2539153

Lindval et al (1997) The binding mode of calyculin A to protein phosphatase-1. J.Biol.Chem. 272 23312 PMID: 9287341

McCluskey et al (2002) Serine-threonine protein phosphatase inhibitors: development of therapeutic strategies. J.Med.Chem. 45 1151 PMID: 11881984

If you know of a relevant reference for Calyculin A, please let us know.

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关键词: Calyculin A, Calyculin A supplier, Protein, phosphatase, 1, 2A, inhibitors, inhibits, Calcineurin, Ser/Thr, Phosphatases, PP1, PP2A, CalyculinA, 1336, Tocris Bioscience