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Cambinol

Cat. No. 7137 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： nSMase2 inhibitor
化学名： 2,3-Dihydro-5-[(2-hydroxy-1-naphthalenyl)methyl]-6-phenyl-2-thioxo-4(1H)-pyrimidinone
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Cambinol

Cambinol is a neutral sphingomyelinase-2 (nSMase2) inhibitor (Ki = 7 μM; IC50 ~ 7.7 μM). In vitro, Cambinol suppresses extracellular vesicle production and inhibits cell-to-cell tau propagation in tau biosensor cells. In vivo, Cambinol decreases tumor necrosis factor-α or interleukin-1β-induced increases of ceramide and cell death in primary neurons. Cambinol is neuroprotective and brain penetrant. Cambinol inhibits the activity of human SIRT1 and SIRT2 and exerts antitumor activity in vitro and in mouse xenograft studies.

技术数据 for Cambinol

分子量 360.43
公式 C21H16N2O2S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 14513-15-6
PubChem ID 3246390
InChI Key RVNSQVIUFZVNAU-UHFFFAOYSA-N
Smiles OC1=C(C2=CC=CC=C2C=C1)CC3=C(C4=CC=CC=C4)NC(NC3=O)=S

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Cambinol

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 36.04 100

制备储备液 for Cambinol

以下数据基于产品分子量 360.43。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.87 mL 27.74 mL
5 mM 0.55 mL 2.77 mL 5.55 mL
10 mM 0.28 mL 1.39 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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参考文献 for Cambinol

参考文献是支持产品生物活性的出版物。

Figuera-Losada et al (2015) Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties. PLoS One 10 e0124481 PMID: 26010541

Stepanek et al (2019) Neutral sphingomyelinase 2 inhibitors based on the 4-(1H-imidazol-2-yl)-2,6-dialkoxyphenol scaffold. Eur.J.Med.Chem. 170 276 PMID: 30921693

Sackmann et al (2019) Inhibition of nSMase2 reduces the transfer of oligomeric α-synuclein irrespective of hypoxia. Front.Mol.Neurosci. 12 200 PMID: 31555088

Bilousova (2018) Suppression of tau propagation using an inhibitor that targets the DK-switch of nSMase2. Biochem.Biophys.Res.Commun. 499 751 PMID: 29604274

Heltweg et al (2006) Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res. 66 4368 PMID: 16618762

If you know of a relevant reference for Cambinol, please let us know.

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关键词: Cambinol, Cambinol supplier, neutral, sphingomyelinase, 2, nSMase2, inhibition, inhibitors, inhibits, Sphingomyelin, SMase, brain, penetrant, SIRT1, SIRT2, antitumor, tau, Other, Hydrolases, Class, III, HDACs, (Sirtuins), 7137, Tocris Bioscience

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