Camptothecin

Cat. No. 1100 6 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： DNA topoisomerase inhibitor

化学名： (S)-4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

纯度： ≥98% (HPLC)

引用文献 (6)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Camptothecin

Camptothecin is a cytotoxic plant alkaloid with antitumor properties; prototypic DNA topoisomerase I inhibitor. Induces single strand DNA breaks and protein-DNA crosslinks.

技术数据 for Camptothecin

分子量	348.36
公式	C₂₀H₁₆N₂O₄
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	7689-03-4
PubChem ID	24360
InChI Key	VSJKWCGYPAHWDS-FQEVSTJZSA-N
Smiles	O=C4C5=C([C@](CC)(O)C(OC5)=O)C=C3C2=NC1=CC=CC=C1C=C2CN34

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Camptothecin

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO		5

制备储备液 for Camptothecin

以下数据基于产品分子量 348.36。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.05 mM	57.41 mL	287.06 mL	574.12 mL
0.25 mM	11.48 mL	57.41 mL	114.82 mL
0.5 mM	5.74 mL	28.71 mL	57.41 mL
2.5 mM	1.15 mL	5.74 mL	11.48 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for Camptothecin

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Camptothecin

参考文献是支持产品生物活性的出版物。

Liu (1989) DNA topoisomerase poisons as antitumour drugs. Annu.Rev.Biochem 58 351 PMID: 2549853

Hsiang et al (1985) Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J.Biol.Chem. 260 14873 PMID: 2997227

Pantazis et al (1993) Camptothecin derivatives induce regression of human ovarian carcinomas grown in nude mice and distinguish between non-tumorigenic and tumorigenic cells in vitro. Int.J.Cancer 53 863 PMID: 8449612

Merck Index 12 1783

If you know of a relevant reference for Camptothecin, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 DNA Topoisomerase Inhibitors

关键词: Camptothecin, Camptothecin supplier, DNA, topoisomerases, inhibitors, inhibits, Isomerases, chemotherapeutics, Topoisomerase, 1100, Tocris Bioscience

6 篇 Camptothecin 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Camptothecin 的部分引用包括：

Ma et al (2005) Oxygen-sensitive {δ}-opioid receptor-regulated survival and death signals: novel insights into neuronal preconditioning and protection. Sci Rep 280 16208 PMID: 15687501

Neveu et al (2016) CLIC5: a novel ETV6 target gene in childhood acute lymphoblastic leukemia. Haematologica PMID: 27540136

Hellinger et al (2013) Immunosuppressive activity of an aqueous Viola tricolor herbal extract. J Ethnopharmacol 151 299 PMID: 24216163

Gründemann et al (2013) Cyclotides Suppress Human T-Lymphocyte Proliferation by an Interleukin 2-Dependent Mechanism. PLoS One 8 e68016 PMID: 23840803

Lamy et al (2013) Preclinical evaluation of 4-methylthiobutyl isothiocyanate on liver cancer and cancer stem cells with different p53 status. PLoS One 8 e70846 PMID: 23936472

Herz et al (2017) Evaluation of an Aqueous Extract from Horseradish Root (Armoracia rusticana Radix) against Lipopolysaccharide-Induced Cellular Inflammation Reaction. Evid Based Complement Alternat Med 2017 1950692 PMID: 28182113

您是否知道使用了 Tocris Camptothecin 的优秀论文？请告知我们.

Camptothecin 的评论

目前没有该产品的评论。 Be the first to review Camptothecin and earn rewards!

Have you used Camptothecin?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Huntington's Disease Research Product Guide

This product guide provides a background to Huntington's disease research and lists around 100 products for the study of:

Somatic Instability
Proteolysis and Inclusion Bodies
Transcriptional Dysregulation
Mitochondrial Dysfunction
Nuclear-Cytoplasmic Transport Interference
Excitotoxicity
Stem Cells

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.