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Submit ReviewCantharidin
说明： Protein phosphatase 1 and 2A inhibitor
化学名： (3aα,4β,7β,7aα)-Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzofuran-1,3-dione
生物活性 for Cantharidin
Cantharidin is a natural toxin inhibitor of protein phosphatases 1 and 2A (Ki values are 1.1 and 0.19 μM respectively); similar to okadaic acid (Cat. No. 1136). Displays > 500-fold selectivity over PP2B.
技术数据 for Cantharidin
| 分子量 | 196.2 |
| 公式 | C10H12O4 |
| 储存 | Store at RT |
| CAS Number | 56-25-7 |
| PubChem ID | 5944 |
| InChI Key | DHZBEENLJMYSHQ-XCVPVQRUSA-N |
| Smiles | O=C(O2)[C@]1(C)[C@H](O3)CC[C@H]3[C@@](C)1C2=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Cantharidin
参考文献 for Cantharidin
参考文献是支持产品生物活性的出版物。
Eldridge and Casida (1995) Cantharidin effects on protein phosphatases and the phosphorylation state of phosphoproteins in mice. Toxicol.Appl.Pharmacol. 130 95 PMID: 7839375
Honkanen (1993) Cantharidin, another natural toxin that inhibits the activity of serine/threonine protein phosphatases types 1 and 2A. FEBS Lett. 330 283 PMID: 8397101
Knapp et al (1999) The protein phosphatase inhibitor cantharidin alters vascular endothelial cell permeability. J.Pharmacol.Exp.Ther. 289 1480 PMID: 10336542
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关键词: Cantharidin, Cantharidin supplier, Protein, phosphatase, 1, 2A, inhibitors, inhibits, Calcineurin, Ser/Thr, Phosphatases, PP1, PP2A, 1548, Tocris Bioscience
5 篇 Cantharidin 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Cantharidin 的部分引用包括：
Shuhaibar et al (2017) Dephosphorylation of the NPR2 guanylyl cyclase contributes to inhibition of bone growth by fibroblast growth factor. Elife 6 PMID: 29199951
Lang et al (2019) Single-Cell Sequencing of iPSC-DA Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes. Cell Stem Cell 24 93 PMID: 30503143
Gray et al (2014) Inhibitory interactions between phosphorylation sites in the C terminus of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor GluA1 subunits. Cell Death Dis 289 14600 PMID: 24706758
Polito et al (2015) Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3). J Biol Chem 2 PMID: 26465004
Egbert et al (2014) Dephosphorylation and inactivation of NPR2 guanylyl cyclase in granulosa cells contributes to the LH-induced decrease in cGMP that causes resumption of meiosis in rat oocytes. Development 141 3594 PMID: 25183874
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