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Submit ReviewCarbamoylcholine chloride
说明： Non-selective cholinergic agonist
别名： Carbachol
化学名： (2-Hydroxyethyl)trimethylammonium chloride carbamate
生物活性 for Carbamoylcholine chloride
Carbamoylcholine chloride is a cholinergic receptor agonist that is resistant to the action of cholinesterases. Blocks apoptosis in cerebellar granule neurons.
技术数据 for Carbamoylcholine chloride
| 分子量 | 182.65 |
| 公式 | C6H15ClN2O2 |
| 储存 | Desiccate at RT |
| CAS Number | 51-83-2 |
| PubChem ID | 5831 |
| InChI Key | AIXAANGOTKPUOY-UHFFFAOYSA-N |
| Smiles | NC(OCC[N+](C)(C)C)=O.[Cl-] |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Carbamoylcholine chloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 18.27 | 100 | |
| DMSO | 9.13 | 50 |
制备储备液 for Carbamoylcholine chloride
以下数据基于产品分子量 182.65。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.47 mL | 27.37 mL | 54.75 mL |
| 5 mM | 1.09 mL | 5.47 mL | 10.95 mL |
| 10 mM | 0.55 mL | 2.74 mL | 5.47 mL |
| 50 mM | 0.11 mL | 0.55 mL | 1.09 mL |
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产品说明书 for Carbamoylcholine chloride
参考文献 for Carbamoylcholine chloride
参考文献是支持产品生物活性的出版物。
Yan et al (1995) Activation of muscarinic cholinergic receptors blocks apoptosis of cultured cerebellar granule neurons. Mol.Pharmacol. 47 248 PMID: 7870032
If you know of a relevant reference for Carbamoylcholine chloride, please let us know.
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关键词: Carbamoylcholine chloride, Carbamoylcholine chloride supplier, Cholinergic, receptor, agonists, Muscarinic, Receptors, Acetylcholine, Nicotinic, Non-Selective, Subtypes, nAChR, Carbachol, Non-selective, Muscarinics, (Non-selective), 2810, Tocris Bioscience
11 篇 Carbamoylcholine chloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Carbamoylcholine chloride 的部分引用包括：
Herrera-Rincon et al (2017) The brain is required for normal muscle and nerve patterning during early Xenopus development. Nat Commun 8 587 PMID: 28943634
Athilingam et al (2017) Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons. Elife 6 PMID: 29206101
Jovancevic et al (2017) Medium-chain fatty acids modulate myocardial function via a cardiac odorant receptor. Basic Res Cardiol 112 13 PMID: 28116519
Deng et al (2013) Label-free cell phenotypic assessment of the biased agonism and efficacy of agonists at the endogenous muscarinic M3 receptors. J Pharmacol Toxicol Methods 68 323 PMID: 23933114
Ebner et al (2019) Optically Induced Calcium-Dependent Gene Activation and Labeling of Active Neurons Using CaMPARI and Cal-Light. Front Synaptic Neurosci 11 16 PMID: 31178713
Hwangpo et al (2012) G Protein-regulated inducer of neurite outgrowth (GRIN) modulates Sprouty protein repression of mitogen-activated protein kinase (MAPK) activation by growth factor stimulation. J Biol Chem 287 13674 PMID: 22383529
Tozzi (2018) DA D2 receptor-mediated neuroprotection in a G2019S Lrrk2 genetic model of Parkinson’s disease. Cell Death Dis 9 204 PMID: 29434188
Goswami et al (2015) Motilin Stimulates Gastric Acid Secretion in Coordination with Ghrelin in Suncus murinus. PLoS One 10 e0131554 PMID: 26115342
Svalø et al (2015) Functional and molecular evidence for Kv7 channel subtypes in human detrusor from patients with and without bladder outflow obstruction. Front Cell Neurosci 10 e0117350 PMID: 25692982
Martin et al (2015) Endocannabinoids Mediate Muscarinic Acetylcholine Receptor-Dependent Long-Term Depression in the Adult Medial Prefrontal Cortex. Stem Cell Reports 9 457 PMID: 26648844
Silva et al (2007) Melatonin inhibits nitric oxide production by microvascular endothelial cells in vivo and in vitro. Br J Pharmacol 151 195 PMID: 17375079
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Carbamoylcholine chloride 的评论
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Carbachol releases Ca2+ from ER stores in HEK293 cells..
By
Anonymous on 12/15/2018
分析类型： In Vitro
种属： Human
细胞系/组织： HEK293
HEK293 cells were loaded with 1 µM cytosolic Ca2+ sensitive dye, Fura-2AM in normal tyrode solution for 30 min and excited alternately at 340 and 380 nm and fluorescence was captured at 510 nm. ER Ca2+ store was depleted with 100 µM carbachol (CCh) in nominally Ca2+ free tyrode solution, resulting in transient cytosolic Ca2+ peak.
该领域的文献
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.