Carbenoxolone disodium

Cat. No. 3096 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Gap junction blocker. Also inhibitor of 11 β-hydroxysteroid dehydrogenase

化学名： (3β,20β)-3-(3-Carboxy-1-oxopropoxy)-11-oxoolean-12-en-29-oic acid disodium

纯度： ≥98% (HPLC)

引用文献 (5)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Carbenoxolone disodium

Carbenoxolone disodium is a glucocorticoid that inhibits 11β-hydroxysteroid dehydrogenase (11-HSD) and blocks gap junction communication.

技术数据 for Carbenoxolone disodium

分子量	614.72
公式	C₃₄H₄₈Na₂O₇
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	7421-40-1
PubChem ID	636402
InChI Key	BQENDLAVTKRQMS-SBBGFIFASA-L
Smiles	[Na+].[Na+].[H][C@@]12C[C@](C)(CC[C@]1(C)CC[C@]1(C)C2=CC(=O)[C@]2([H])[C@@]3(C)CC[C@H](OC(=O)CCC([O-])=O)C(C)(C)[C@]3([H])CC[C@@]12C)C([O-])=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Carbenoxolone disodium

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	61.47	100

制备储备液 for Carbenoxolone disodium

以下数据基于产品分子量 614.72。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.63 mL	8.13 mL	16.27 mL
5 mM	0.33 mL	1.63 mL	3.25 mL
10 mM	0.16 mL	0.81 mL	1.63 mL
50 mM	0.03 mL	0.16 mL	0.33 mL

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产品说明书 for Carbenoxolone disodium

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Carbenoxolone disodium

参考文献是支持产品生物活性的出版物。

Jellinck et al (1993) Differential inhibition of 11 beta-hydroxysteroid dehydrogenase by carbenoxolone in rat brain regions and peripheral tissues. J.Steroid Biochem.Mol.Biol. 46 209 PMID: 8664169

Sagar and Larson (2006) Carbenoxolone inhibits junctional trasnfer and upregulates connexin43 expression by a protein kinase A-dependent pathway. J.Cell.Biochem. 98 1543 PMID: 16552723

If you know of a relevant reference for Carbenoxolone disodium, please let us know.

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关键词: Carbenoxolone disodium, Carbenoxolone disodium supplier, Gap, junction, blockers, inhibitors, inhibits, 11, β-hydroxysteroid, beta-hydroxysteroid, dehydrogenase, gap, Connexins, Channels, Dehydrogenases, 11b-Hydroxysteroid, Dehydrogenase, 3096, Tocris Bioscience