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Submit ReviewCarboxy-PTIO, potassium salt
说明： Stable, water-soluble deactivator of NO
化学名： 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide, potassium salt
生物活性 for Carboxy-PTIO, potassium salt
A stable, water-soluble free radical that reacts stoichiometrically with NO. Almost twice as strong an inhibitor as N(ω)-nitroarginine or N-methylarginine.
技术数据 for Carboxy-PTIO, potassium salt
| 分子量 | 315.38 |
| 公式 | C14H16KN2O4 |
| 储存 | Desiccate at -20°C |
| CAS Number | 148819-94-7 |
| PubChem ID | 2733502 |
| InChI Key | VYEUQMVIGXFZQU-UHFFFAOYSA-M |
| Smiles | [K+].CC1(C)N([O])C(C2=CC=C(C=C2)C([O-])=O)=[N+]([O-])C1(C)C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Carboxy-PTIO, potassium salt
参考文献 for Carboxy-PTIO, potassium salt
参考文献是支持产品生物活性的出版物。
Akaike et al (1993) Antagonistic action of imidazolineoxy N-oxides against endothelium-derived relaxing factor/NO through a radical reaction. Biochemistry 32 827 PMID: 8422387
Rand and Li (1995) Discrimination by the NO-trapping agent, carboxy-PTIO, between NO and the nitrergic transmitter but not between NO and EDRF. Br.J.Pharmacol. 116 1906 PMID: 8528578
Tsunoda et al (1994) Vasodilator effect of carboxy-2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl in the coronary circulation: in vivo and in vitro studies. Eur.J.Pharmacol. 262 55 PMID: 7813579
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关键词: Carboxy-PTIO, potassium salt, Carboxy-PTIO, potassium salt supplier, Stable, water-soluble, deactivators, NO, Nitric, Oxide, Signaling, Signalling, free, radical, Other, 0772, Tocris Bioscience
11 篇 Carboxy-PTIO, potassium salt 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Carboxy-PTIO, potassium salt 的部分引用包括：
Echeverría et al (2014) Endotoxin induces fibrosis in vascular endothelial cells through a mechanism dependent on transient receptor protein melastatin 7 activity. PLoS One 9 e94146 PMID: 24710004
Quock et al (2011) The acute antinociceptive effect of HBO2 is mediated by a NO-cyclic GMP-PKG-KATP channel pathway in mice. Brain Res 1368 102 PMID: 20977894
Carlile et al (2012) An anxiolytic-like effect of hyperbaric oxygen in the mouse light/dark exploration test. Life Sci 90 267 PMID: 22154905
Clark et al (2015) Selective activation of microglia facilitates synaptic strength. Cardiovasc Res 35 4552 PMID: 25788673
Jin et al (2012) Activation of the cGMP/Protein Kinase G Pathway by Nitric Oxide Can Decrease TRPV1 Activity in Cultured Rat Dorsal Root Ganglion Neurons. Korean J Physiol Pharmacol 16 211 PMID: 22802704
Ota et al (2010) Synaptic plasticity and NO-cGMP-PKG signaling coordinately regulate ERK-driven gene expression in the lateral amygdala and in the auditory thalamus following Pavlovian fear conditioning. Learn Mem 17 221 PMID: 20351057
Ping and Schafe (2010) The NO-cGMP-PKG signaling pathway coordinately regulates ERK and ERK-driven gene expression at pre- and postsynaptic sites following LTP-inducing stimulation of thalamo-amygdala synapses. Neural Plast 2010 540940 PMID: 21461354
Ota et al (2010) Synaptic plasticity and NO-cGMP-PKG signaling regulate pre- and postsynaptic alterations at rat lateral amygdala synapses following fear conditioning. PLoS One 5 e11236 PMID: 20574537
Ormerod et al (2011) The role of vascular myoglobin in nitrite-mediated blood vessel relaxation. Br J Pharmacol 89 560 PMID: 20889759
Chan et al (2007) Protein kinase C-dependent mitochondrial translocation of proapoptotic protein Bax on activation of inducible nitric-oxide synthase in rostral ventrolateral medulla mediates cardiovascular depression during experimental endotoxemia. Mol Pharmacol 71 1129 PMID: 17227955
Yang (2007) Modulation of inhibitory activity by nitric oxide in the thalamus. J Neurophysiol 97 3386 PMID: 17376843
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