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Submit ReviewCBiPES hydrochloride
Discontinued Product
3949 has been discontinued.
View all Glutamate (Metabotropic) Group II Receptors products.
说明： Positive allosteric modulator of mGlu2 receptors
化学名： N-(4'-Cyano-[1,1'-biphenyl]-3-yl-N-(3-pyridinylmethyl)-ethanesulfonamide hydrochloride
纯度： ≥99% (HPLC)
生物活性 for CBiPES hydrochloride
Selective positive allosteric modulator of the mGlu2 receptor (IC50 = 98.2 nM). Mimics the action of LY 379268 (Cat. No. 2453); attenuates ketamine-evoked histamine release in vivo.
技术数据 for CBiPES hydrochloride
| 分子量 | 413.92 |
| 公式 | C21H19N3O2S.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 856702-40-4 |
| PubChem ID | 71532792 |
| InChI Key | QKUHSVQWWZBAKM-UHFFFAOYSA-N |
| Smiles | O=S(N(CC2=CC=CN=C2)C1=CC(C3=CC=C(C#N)C=C3)=CC=C1)(CC)=O.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for CBiPES hydrochloride
参考文献 for CBiPES hydrochloride
参考文献是支持产品生物活性的出版物。
Johnson et al (2005) Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s). Psychopharmacology. 179 271 PMID: 15717213
Fell et al (2010) Activation of metabotropic glutamate receptors (mGlu)2 receptors suppresses histamine release in limbic brain regions following acute KA challenge. Neuropharmacology. 58 632 PMID: 19951716
关键词: CBiPES hydrochloride, CBiPES hydrochloride supplier, positive, allosteric, modulators, PAMs, mGlu2, mGluR2, metabotropic, glutamate, group, II, receptors, Glutamate, (Metabotropic), Group, Receptors, 3949, Tocris Bioscience
1 篇 CBiPES hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CBiPES hydrochloride 的部分引用包括：
Yin et al (2014) Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS. J Neurosci 34 79 PMID: 24381270
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