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CBR 5884

Cat. No. 5836 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5836 has been discontinued.

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说明： Phosphoglycerate dehydrogenase (PHGDH) inhibitor
化学名： Ethyl 5-[(2-furanylcarbonyl)amino]-3-methyl-4-thiocyanato-2-thiophenecarboxylate
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
文献 (2)
生物活性 技术数据 说明书 参考文献

生物活性 for CBR 5884

CBR 5884 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50 = 33 μM). Decreases de novo serine synthesis in cancer cells. Inhibits proliferation of cancer cell lines having high PHGDH expression levels.

技术数据 for CBR 5884

分子量 336.39
公式 C14H12N2O4S2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 681159-27-3
PubChem ID 4674993
InChI Key QBVIRPJBDIZKBC-UHFFFAOYSA-N
Smiles CCOC(C1=C(C(SC#N)=C(S1)NC(C2=CC=CO2)=O)C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for CBR 5884

参考文献是支持产品生物活性的出版物。

Mullarky et al (2016) Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers. Proc.Natl.Acad.Sci.U.S.A. 113 1778 PMID: 26831078

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关键词: CBR 5884, CBR 5884 supplier, CBR5884, PHGDH, 3-phosphoglycerate, dehydrogenases, inhibitors, inhibits, serine, synthesis, cancer, Other, Dehydrogenases, 5836, Tocris Bioscience

2 篇 CBR 5884 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CBR 5884 的部分引用包括：

Nigdelioglu et al (2016) Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production. J Biol Chem 291 27239 PMID: 27836973

Sen et al (2018) EWS-FLI1 reprograms the metabolism of Ewing sarcoma cells via positive regulation of glutamine import and serine-glycine biosynthesis. Mol Carcinog 57 1342 PMID: 29873416

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