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Submit ReviewCCF 642
说明： Protein disulfide isomerase (PDI) inhibitor
化学名： 3-(4-Methoxyphenyl)-5-[(5-nitro-2-thienyl)methylene]-2-thioxo-4-thiazolidinone
纯度： ≥98% (HPLC)
生物活性 for CCF 642
CCF 642 is a protein disulfide isomerase (PDI) inhibitor. Induces acute ER stress and apoptosis in multiple myeloma cells in vitro (submicromolar activity). Prolongs survival of C57BL/KaLwRij mice engrafted with 5TGM1-luc myeloma. Also a bone marrow-sparing compound.
技术数据 for CCF 642
| 分子量 | 378.45 |
| 公式 | C15H10N2O4S3 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 346640-08-2 |
| PubChem ID | 1820764 |
| InChI Key | SPYIETQLOVDJCF-XYOKQWHBSA-N |
| Smiles | COC1=CC=C(N2C(S/C(C2=O)=C/C3=CC=C([N+]([O-])=O)S3)=S)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for CCF 642
参考文献 for CCF 642
参考文献是支持产品生物活性的出版物。
Vatolin et al (2016) Novel protein disulfide isomerase inhibitor with anticancer activity in multiple myeloma. Cancer Res. 76 3340 PMID: 27197150
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关键词: CCF 642, CCF 642 supplier, CCF642, protein, disulfide, isomerases, PDI, inhibitors, inhibits, cancer, multiple, myeloma, cells, Protein, Disulfide, Isomerase, 6063, Tocris Bioscience
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Gut Hormones Poster
The gastrointestinal tract is the largest endocrine gland in the human body, secreting hormones that affect digestion, appetite and energy expenditure. Neuropeptide modulators and gut hormones that influence appetite are reviewed in this poster.