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Submit ReviewCCG 50014
Discontinued Product
4567 has been discontinued.
View all Heterotrimeric G-protein GTPases products.
说明： Potent and selective inhibitor of regulator of G-protein signaling 4 (RGS4) protein
化学名： 4-[(4-Fluorophenyl)methyl]-2-(4-methylphenyl)-1,2,4-thiadiazolidine-3,5-dione
纯度： ≥98% (HPLC)
生物活性 for CCG 50014
CCG 50014 is a potent and selective inhibitor of regulator of G-protein signaling 4 (RGS4) protein (IC50 values are 30.1 nM and 11.0 μM for RGS4 and RGS8 respectively). Exhibits >20-fold selectivity for RGS4 over other RGS proteins.
技术数据 for CCG 50014
| 分子量 | 316.35 |
| 公式 | C16H13FN2O2S |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 883050-24-6 |
| PubChem ID | 2733079 |
| InChI Key | QUIIIYITNGOFEI-UHFFFAOYSA-N |
| Smiles | FC(C=C3)=CC=C3CN(C(N(C2=CC=C(C)C=C2)S1)=O)C1=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for CCG 50014
参考文献 for CCG 50014
参考文献是支持产品生物活性的出版物。
Blazer et al (2011) A nanomolar potency small molecule inhibitor of regulator of G protein signaling (RGS) proteins. Biochemistry 50 3181 PMID: 21329361
Turner et al (2012) Small molecule inhibitors of regulators of G protein signalling (RGS) proteins. ACS Med.Chem.Lett. 3 146 PMID: 22368763
Vashisth et al (2013) Conformational dynamics of a regulator of g-protein signaling protein reveals a mechanism of allosteric inhibition by a small molecule. ACS Chem.Biol. 8 2778 PMID: 24093330
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关键词: CCG 50014, CCG 50014 supplier, CCG50014, potent, selective, RGS4, inhibitors, inhibits, regulator, G-protein, signaling, signalling, Heterotrimeric, GTPases, 4567, Tocris Bioscience
1 篇 CCG 50014 的引用文献
引用文献是使用了 Tocris 产品的出版物。 CCG 50014 的部分引用包括：
Kee K et al (2022) Bisphenol-A impairs synaptic formation and function by RGS4-mediated regulation of BDNF signaling in the cerebral cortex. Dis Model Mech 15 PMID: 35781563
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