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说明： Used to characterize GluN2B-containing NMDA receptors
化学名： 2-Carboxy-3-carboxymethylquinoline
生物活性 for CCMQ
For use in conjunction with [3H]-homoquinolinic acid to characterize GluN2B (formally NR2B) containing NMDA receptors; selectively inhibits [3H]-homoquinolinic acid binding to non-NMDA sensitive sites.
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
技术数据 for CCMQ
| 分子量 | 231.21 |
| 公式 | C12H9NO4 |
| 储存 | Desiccate at +4°C |
| CAS Number | 132623-44-0 |
| PubChem ID | 3337816 |
| InChI Key | IFXJDEHFADWURH-UHFFFAOYSA-N |
| Smiles | OC(=O)CC1=C(N=C2C=CC=CC2=C1)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for CCMQ
参考文献 for CCMQ
参考文献是支持产品生物活性的出版物。
Brown et al (1998) [3H]-Homoquinolinate binds to a subpopulation of NMDA receptors and to a novel binding site. J.Neurochem. 71 1464 PMID: 9751179
关键词: CCMQ, CCMQ supplier, characterize, NR2B-containing, NMDA, receptors, Glutamate, Receptors, N-Methyl-D-Aspartate, iGlu, Ionotropic, GluN2B, 1238, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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- Excitotoxicity
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Huntington's Disease Poster
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.