CD38 inhibitor 78c

Cat. No. 6391 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent CD38 inhibitor; active in vivo

化学名： 4-[[trans-4-(2-Methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)-2(1H)-quinolinone

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for CD38 inhibitor 78c

CD38 inhibitor 78c is a potent CD38 (ADP ribosyl cyclase/hydrolase) inhibitor (IC₅₀ values are 1.9 and 7.3 nM at mouse and human CD38, respectively). Catalyzes breakdown of NAD to nicotinamide and ADPR, and hydrolyzes NAADP to adenosine-5'-O-diphosphoribose phosphate. Elevates NAD⁺ levels >5-fold in liver and >1.2-fold in muscle of diet-induced obese (DIO) C57Bl6 mice. Also prevents age-related NAD⁺ decline in mice. Improves glucose intolerance, cardiac function and improves physiological and metabolic parameters in old mice.

技术数据 for CD38 inhibitor 78c

分子量	413.54
公式	C₂₂H₂₇N₃O₃S
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1700637-55-3
PubChem ID	118736856
InChI Key	VJQALSOBHVEJQM-QAQDUYKDSA-N
Smiles	COCCO[C@H]1CC[C@H](NC2=CC(N(C3=CC=C(C4=CN=CS4)C=C23)C)=O)CC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CD38 inhibitor 78c

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	41.35	100

制备储备液 for CD38 inhibitor 78c

以下数据基于产品分子量 413.54。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.42 mL	12.09 mL	24.18 mL
5 mM	0.48 mL	2.42 mL	4.84 mL
10 mM	0.24 mL	1.21 mL	2.42 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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产品说明书 for CD38 inhibitor 78c

分析证书/产品说明书

化学品安全技术说明书

参考文献 for CD38 inhibitor 78c

参考文献是支持产品生物活性的出版物。

Tarrago et al (2018) A potent and specific CD38 inhibitor ameliorates age-related metabolic dysfunction by reversing tissue NAD⁺ decline. Cell Metab. 27 1081 PMID: 29719225

Haffner et al (2015) Discovery, synthesis, and biological evaluation of thiazoloquin(az)olin(on)es as potent CD38 inhibitors. J.Med.Chem. 58 3548 PMID: 25828863

If you know of a relevant reference for CD38 inhibitor 78c, please let us know.

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关键词: CD38 inhibitor, CD38 inhibitor supplier, CD38, inhibitor, 78c, Potent, inhibitors, inhibits, ADP, ribosyl, cyclases, CD157, hydrolases, Other, Hydrolases, 6391, Tocris Bioscience

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